교수소개
사이토카인, 면역관문단백질 등의 면역타깃들에 대한 경구용 저분자화합물 면역치료제 개발 연구를 수행 중이다. 경구용 TNF 억제제는 현재 미국에서 임상1상을 진행하고 있고, 경구용 PD-L1 억제제는 후보물질 도출 중이다. 현재까지 약 총 70여편의 논문을 SCI급 국제학술지에 발표했다. 특히, TNF 외에 IL-1, IL-2, IL-4, IL-6, IL-17 등의 사이토카인 조절제에 대한 관심을 가지고 있으며, 다양한 면역질환에 대한 치료제 개발을 이어나갈 생각이다. 발표된 논문들은 다음 사이트에서 검색 할 수 있다. https://pubmed.ncbi.nlm.nih.gov/?term=heo+th&sort=date
Research topic is study of discovery of oral small molecule immunotherapeutics targeting immunological targets such as cytokine and immune checkpoints. The oral TNF inhibitor is currently undergoing Phase 1 clinical trials in the United States, and the oral PD-L1 inhibitor is being developed as a candidate substance. So far, approximatley 70 papers have been published in SCI-grade international journals. In particular, there is interest in cytokine modulators such as IL-1, IL-2, IL-4, IL-6, IL-17, in addition to TNF, and there are plans to continue developing therapies for various immune disorders. The published papers can be searched on the following website: https://pubmed.ncbi.nlm.nih.gov/?term=heo+th&sort=date
최종학력
2004.08.31 | 서울대학교 | 약학과 | 약학박사
연구실적
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2024.03
| 교신저자
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 제72권 14호, pp.7882-7893
Geraniin Alleviates Inflammation in Caco-2 Cells and Dextran Sulfate Sodium-Induced Colitis Mice by Targeting IL-1β -
2023.11
| 교신저자
| FASEB JOURNAL, 제37권 11호
Aberrant glucose metabolism underlies impaired macrophage differentiation in glycogen storage disease type Ib -
2023.08
| 교신저자
| LIFE SCIENCES, 제326권
IL-17A-targeting fenofibrate attenuates inflammation in psoriasis by inducing autophagy -
2023.05
| 교신저자
| LIFE SCIENCES, 제320권
Chelerythrine, a novel small molecule targeting IL-2, inhibits melanoma progression by blocking the interaction between IL-2 and its receptor -
2023.04
| 교신저자
| PLOS ONE, 제18권 4호, pp.0281834-0281834
Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction -
2023.04
| 교신저자
| BIOMEDICINES, 제11권 4호
LncRNA SNHG4 Modulates EMT Signal and Antitumor Effects in Endometrial Cancer through Transcription Factor SP-1 -
2023.04
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제24권 7호
Butein Inhibits Cell Growth by Blocking the IL-6/IL-6R alpha Interaction in Human Ovarian Cancer and by Regulation of the IL-6/STAT3/FoxO3a Pathway -
2022.03
| 교신저자
| ONCOLOGY REPORTS, 제47권 3호
Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer -
2021.09
| 교신저자
| BIOSCIENCE REPORTS, 제41권 9호
LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition -
2021.08
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제22권 16호
Bazedoxifene, a gp130 inhibitor, modulates emt signaling and exhibits antitumor effects in hpv-positive cervical cancer -
2021.02
| 교신저자
| PHARMACOLOGY
Combination of LMT-28 and Metformin Improves Beneficial Anti-Inflammatory Effect in Collagen-Induced Arthritis -
2020.12
| 교신저자
| CANCERS, 제12권 12호, pp.1-17
Long Noncoding RNA E2F4as Promotes Progression and Predicts Patient Prognosis in Human Ovarian Cancer -
2020.07
| 공동저자
| ARTHRITIS & RHEUMATOLOGY, 제72권 7호, pp.1192-1202
Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis -
2020.04
| 제1저자
| ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 제33권 4호, pp.670-677
In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor -
2020.04
| 교신저자
| CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 제47권 4호, pp.628-639
A directly GP130-targeting small molecule ameliorates collagen-induced arthritis (CIA) by inhibiting IL-6/GP130 signalling and Th17 differentiation -
2020.03
| 교신저자
| CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 제47권 3호, pp.432-438
Comparative effectiveness of different antiplatelet agents at reducing TNF-driven inflammatory responses in a mouse model -
2020.02
| 교신저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제522권 4호, pp.1030-1036
Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis: A combination of LMT-28 and THP alleviates CIA -
2020.01
| 공동저자
| INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 제16권 2호, pp.320-329
E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer -
2020.01
| 교신저자
| INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 제16권 1호, pp.99-115
Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/ beta-catenin signaling pathway -
2019.10
| 공동저자
| VIRUSES-BASEL, 제11권 10호
Plant-Derived Purification, Chemical Synthesis, and In Vitro/In Vivo Evaluation of a Resveratrol Dimer, Viniferin, as an HCV Replication Inhibitor -
2019.04
| 교신저자
| PHARMACOLOGICAL REPORTS, 제71권 2호, pp.266-271
Beneficial anti-inflammatory effects of combined rosuvastatin and cilostazol in a TNF-driven inflammatory model -
2019.04
| 교신저자
| PHARMACOLOGY, 제104권 1-2호, pp.21-27
A Comparison of the Anti-Inflammatory Effects of Four Combined Statin and Antiplatelet Therapies on Tumor Necrosis Factor-Mediated Acute Inflammation in vivo -
2019.03
| 교신저자
| IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 제41권 2호, pp.179-184
Anti-TNF effect of combined pravastatin and cilostazol treatment in an in vivo mouse model -
2018.12
| 교신저자
| CARDIOVASCULAR THERAPEUTICS, 제36권 6호
Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low-density lipoprotein receptor knockout mice -
2018.07
| 교신저자
| BIOLOGICALS, 제54권, pp.8-12
Development of an anti-EPO antibody detection kit based on lab-on-a-chip and bridging antibody technologies -
2018.05
| 공동저자
| NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 제70권 4호, pp.605-619
Antiproliferative Effect of Vine Stem Extract from Spatholobus Suberectus Dunn on Rat C6 Glioma Cells Through Regulation of ROS, Mitochondrial Depolarization, and P21 Protein Expression -
2018.02
| 공동저자
| BIOMEDICINE & PHARMACOTHERAPY, 제98권, pp.726-732
Anti-proliferative effect of Zea mays L. cob extract on rat C6 glioma cells through regulation of glycolysis, mitochondrial ROS, and apoptosis -
2018.01
| 교신저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제495권 1호, pp.300-305
Direct regulation of IL-2 by curcumin -
2017.12
| 교신저자
| CARDIOVASCULAR THERAPEUTICS, 제35권 6호
Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis -
2017.08
| 공동저자
| APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 제182권 4호, pp.1663-1674
Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis -
2016.03
| 교신저자
| PLOS ONE, 제11권 3호, pp.0-0
Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice -
2016.03
| 제1저자
| ONCOTARGET, 제7권 13호, pp.15460-15473
Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer -
2016.03
| 공동저자
| IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 제52권 3호, pp.349-355
Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential -
2016.02
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제26권 4호, pp.1282-1286
Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers -
2016.01
| 교신저자
| BRITISH JOURNAL OF PHARMACOLOGY, 제173권 1호, pp.191-211
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase -
2015.08
| 교신저자
| MOLECULAR PHARMACOLOGY, 제88권 2호, pp.392-400
Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses -
2015.08
| 교신저자
| BIOMEDICINE & PHARMACOTHERAPY, 제74권, pp.133-137
Exacerbation of tumor necrosis factor-induced vascular leak syndrome by aging -
2015.07
| 공동저자
| PLOS ONE, 제10권 7호
NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages -
2015.07
| 교신저자
| JOURNAL OF IMMUNOLOGY, 제195권 1호, pp.237-245
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit, Glycoprotein 130 -
2015.05
| 공동저자
| JOURNAL OF SEPARATION SCIENCE, 제38권, pp.1872-1880
Development and validation of a liquid chromatography with tandem mass spectrometry method for the quantification of vitisin B in rat plasma and urine -
2015.03
| 교신저자
| BIOMEDICINE & PHARMACOTHERAPY, 제70권, pp.213-216
Induction of vascular leak syndrome by tumor necrosis factor-alpha alone -
2014.09
| 교신저자
| BIOLOGICAL RESEARCH, 제47권 1호, pp.42-50
Normalization of the levels of inflammatory molecules in Mycobacterium smegmatis-infected U937 cells by fibrate pretreatment. -
2014.04
| 교신저자
| GENE, 제539권 2호, pp.181-185
Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells -
2013.11
| 교신저자
| ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE, 제19권 6호, pp.54-60
Erythropoietic agents from natural sources -
2013.06
| 교신저자
| NEUROCHEMISTRY INTERNATIONAL, 제62권 7호, pp.931-935
Batten disease is linked to altered expression of mitochondria-related metabolic molecules -
2013.05
| 공동저자
| 대한내과학회지, 제84권 5호, pp.742-746
면역억제 치료 후 Darbapoetin에 반응한 진성 적혈구 무형성증 -
2013.05
| 교신저자
| GENE, 제519권 2호, pp.245-250
Cell cycle arrest in Batten disease lymphoblast cells -
2012.12
| 공동저자
| MUSCLE & NERVE, 제46권 6호, pp.914-916
Normokalemic periodic paralysis is not a distinct disease -
2012.12
| 교신저자
| CELL BIOCHEMISTRY AND FUNCTION, 제30권 8호, pp.677-682
N-acetylcysteine normalizes the urea cycle and DNA repair in cells from patients with Batten disease -
2012.07
| 교신저자
| BIOLOGICALS, 제40권 4호, pp.254-261
Immunogenicity of recombinant human erythropoietin in Korea: A two-year cross-sectional study -
2012.02
| 교신저자
| CHEMICO-BIOLOGICAL INTERACTIONS, 제195권 3호, pp.173-179
Hepatic expression of cytochrome P450 in type 2 diabetic Goto-Kakizaki rats -
2012.01
| 교신저자
| NEUROSCIENCE LETTERS, 제506권 2호, pp.297-302
Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben -
2011.12
| 교신저자
| INTERNATIONAL IMMUNOPHARMACOLOGY, 제11권 12호, pp.2237-2241
Anti-erythropoietin and anti-thrombopoietin antibodies induced after administration of recombinant human erythropoietin -
2011.12
| 교신저자
| INTERNATIONAL IMMUNOPHARMACOLOGY, 제11권 12호, pp.2237-2241
Anti-erythropoietin and anti-thrombopoietin antibodies induced after administration of recombinant human erythropoietin -
2011.10
| 교신저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제414권 1호, pp.49-52
Protective potential of resveratrol against oxidative stress and apoptosis in Batten disease lymphoblast cells -
2011.09
| 교신저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제413권 2호, pp.254-258
Protective effect of catechin in type I Gaucher disease cells by reducing endoplasmic reticulum stress -
2011.08
| 교신저자
| ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 제401권 2호, pp.667-676
Quantitative analysis of specific target DNA oligomers using a DNA-immobilized packed-column system -
2011.08
| 교신저자
| BIOMEDICINE & PHARMACOTHERAPY, 제65권 5호, pp.364-368
Protective effect of recombinant human erythropoietin in type II Gaucher disease patient cells by scavenging endoplasmic reticulum stress -
2010.06
| 교신저자
| JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 제52권 2호, pp.289-293
Application of a bridging ELISA for detection of anti-erythropoietin binding antibodies and a cell-based bioassay for neutralizing antibodies in human sera -
2010.04
| 교신저자
| 응용약물학회지(BIOMOLECULES & THERAPEUTICS), 제18권, pp.184-190
Comparative Analysis of Screening Results from Various ELISA Formats Used for Detection of Anti-Erythropoietin Antibodies in Korean Patients -
2010.08
| 공동저자
| 생명과학회지, 제20권 8호, pp.1281-1286
Resveratrol Upregulates p21, Cell Cycle Regulator, in Gaucher Disease Cells
-
2013.03
| 공동
| 라이프사이언스
감염치료약학 -
2011.09
| 공동
| 라이프사이언스
최신면역학
-
2020.08.10
| 공동발명자
| 호서대학교 산학협력단
핑클루비 추출물을 유효성분으로 함유하는 탈색소성 질환 예방, 개선 또는 치료용 조성물(Composition Comprising Extract of Sedeveria Pink Ruby for Preventing, Improving or Treating Disease Concerning Depigmentation) -
2020.04.22
| 주발명자
| 가톨릭대학교 산학협력단
테트라하이드로파파베린 및 IL-6 억제제를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법(Composition for preventing or treating TNF-mediated diseases comprising tetrahydropapaverine and IL-6 inhibitor, and method for inhibiting TNF-activity with the same) -
2019.05.21
| 주발명자
| 가톨릭대학교 산학협력단
신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법(Composition for Preventing or Treating TNF-mediated Disease Comprising Novel Derivatives and Method for Inhibiting TNF-activity with the Same) -
2019.04.16
| 주발명자
| 동국대학교 산학협력단, 가톨릭대학교 산학협력단
포도근 추출물 또는 이의 분획물을 유효성분으로 포함하는 C형 간염의 예방 또는 치료용 조성물 -
2018.12.27
| 주발명자
| 가톨릭대학교 산학협력단
프라바스타틴(pravastatin) 및 항혈소판제를 유효성분으로 함유하는 신장 질환 예방 또는 치료용 조성물 -
2018.12.26
| 주발명자
| 가톨릭대학교 산학협력단
신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법 -
2017.11.03
| 주발명자
| 가톨릭대학교 산학협력단
사포그릴레이트, 프라바스타틴 및 TNF-억제제를 유효성분으로 포함하는 죽상동맥경화증 예방 또는 치료용 약학조성물(Pharmaceutical composition for preventing or treating atherosclerosis comprising sarpogrelate, pravastatin and TNF-inhibitor) -
2017.08.31
| 주발명자
| 가톨릭대학교 산학협력단
실시간 세포관찰 시스템을 이용한 조혈작용 약물 스크리닝 방법 및 이의 배지 조성물(Methods for screening of erythropoiesis-stimulating agents using time-lapse real time cell image system and medium composition thereof) -
2017.02.21
| 주발명자
| 가톨릭대학교 산학협력단
EPO 수용체 및 PKC 동시 표적물질을 유효성분으로 포함하는 빈혈의 예방 또는 치료용 약학 조성물 및 이의 용도(Pharmaceutical composition for preventing or treating anemia comprising agent targeting EPO receptor as well as PKC as an active ingredient and the use thereof) -
2016.01.06
| 주발명자
| 가톨릭대학교 산학협력단,동국대학교 산학협력단
C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도(Resveratrol multimers with selective inhibitory of genome replication of HCV and use thereof) -
2015.07.17
| 주발명자
| 가톨릭대학교 산학협력단
자가면역 항체 검출방법 및 이를 이용한 자가면역 항체 검출키트(A Method for Detecting Autoimmuneantibody and Kit Using It) -
2014.12.16
| 공동발명자
| 가톨릭대학교 산학협력단,동국대학교 산학협력단
포도근 추출물 또는 이의 분획물을 유효성분으로 포함하는 C형 간염의 예방 또는 치료용 조성물(Composition for the prevention or treatment of Hepatitis C, comprising extracts or fractions of Vitidis Vinferae Radix as an effective ingredient)
-
2022.08.01
| 주발명자
| ㈜아이랩
“IL-6 생리활성을 억제하는 저분자화합물 발굴을 위한 탐색적 연구” 의 기술·노하우 이전 -
2019.08.19
| 주발명자
| ㈜아이랩
‘신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제방법’의 특허양도(매매) 건 -
2017.11.22
| 주발명자
| (주)아이랩
‘신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제방법’의 기술이전 건 -
2016.11.16
| 주발명자
| ㈜바이오코아
“항-제9응고인자 항체의 검출 방법 및 검출 키트” 실시계약 -
2016.01.11
| 주발명자
| ㈜ 나노엔텍
실시간 세포관찰 시스템을 이용한 조혈작용 약물 스크리닝 프로토콜 및 조혈기능 개선약물 개발 -
2014.01.02
| 주발명자
| 나노앤텍
자가면역 항체 검출방법 및 이를 이용한 자가면역 항체 검출키트