윤기동 교수
Yoon Kee Dong
- 02-2164-4091
- kdyoon@catholic.ac.kr
- 정진석추기경약학관 NP405
연구분야
생약학, 천연물화학
연구키워드
천연성분 분리
구조분석
정성 및 정량평가
교수소개
1. 학력 - 학사 (서울대학교 약학과), - 석사 (서울대학교 대학원 약학과), - 박사 (서울대학교 대학원 약학과) - 석사 및 박사 세부전공: 생약학 (Pharmacognosy) - 박사후연구원: 미국의 Columbia University Medical Center( 눈의 황반변성을 유발하는 독성물질의 규명) 2. 현재 위치 - 직위: 가톨릭대학교 약학대학 약학과 교수 - 대학원 연구실 운영: 생약학/천연물화학 연구실 (https://sites.google.com/view/pnmrlab) - 연구내용: 국내외 유래 생약 및 약용식물의 주요성분 및 생리활성 성분을 분리 규명/ 기업과의 공동연구를 통해 천연물의약품 및 건강기능식품, 화장품의 지표성분 및 활성성분 탐색/ 천연물제품의 품질평가를 위한 정량, 정성평가법 개발
1. Education and Background: - PhD in Pharmacy (Pharmacognosy): Seoul National University - MS in Pharmacy (Pharmacognosy): Seoul National University - BS in Pharmacy: Seoul National University 2. Postdoctoral Research: - Columbia University Medical Center - Research topic: Identification of toxic substances that cause macular degeneration 3. Current Position: - Professor, College of Pharmacy, The Catholic University of Korea - Research Interests: Isolation and characterization of major and bioactive constituents from medicinal plants and herbs / Development of quality control methods for natural products 4. Collaborative Research: - Collaborated with numerous companies to develop marker compound identification, quantification, and qualitative evaluation methods for natural medicines, health functional foods, and cosmetics - Contributed to the quality control and maintenance of natural product 5. Key Achievements: - Identified and characterized several novel bioactive compounds from natural sources - Developed innovative methods for the quality control of natural products - Contributed to the advancement of natural product research and development - Published numerous papers in peer-reviewed journals - Awarded several research grants - Served as a member of various academic societies
최종학력
2008.08.26 | 서울대학교 | Pharmacy | 약학박사 (생약학 전공)
연구실적
-
2025.08
| 교신저자
| MOLECULES, 제30권 16호
Three New Prenylated Dihydrobenzofurans and a New Flavonoid Glycoside from the Aerial Parts of Myrsine seguinii -
2025.06
| 교신저자
| Korean Journal of Pharmacognosy, 제56권 2호, pp.117-122
Development of Quantitative Analysis Method for Liriope platyphylla Extract Using Spicatoside A -
2024.07
| 교신저자
| MOLECULES, 제29권 13호
IL-6 Inhibitory Compounds from the Aerial Parts of Piper attenuatum and Their Anticancer Activities on Ovarian Cancer Cell Lines -
2024.06
| 교신저자
| Natural Product Sciences, 제30권 2호, pp.72-79
A New Vomifoliol Derivative and Flavonoids from the Aerial Parts of Orthosiphon aristatus -
2024.03
| 교신저자
| Korean Journal of Pharmacognosy, 제55권 1호, pp.8-14
Iridoid Glycoside and Procyanidins from Tejocote -
2023.12
| 교신저자
| Natural Product Sciences, 제29권 4호, pp.268-275
A New Bicyclic Megastigmane Derivative from By-product of Ginseng Berry Extract -
2023.04
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제24권 7호
Butein Inhibits Cell Growth by Blocking the IL-6/IL-6R alpha Interaction in Human Ovarian Cancer and by Regulation of the IL-6/STAT3/FoxO3a Pathway -
2022.12
| 공동저자
| BIOMEDICINE & PHARMACOTHERAPY, 제156권
Kaempferol tetrasaccharides restore skin atrophy via PDK1 inhibition in human skin cells and tissues: Bench and clinical studies -
2021.12
| 교신저자
| Natural Product Sciences, 제27권 4호, pp.240-244
Chemical Constituents from Aegle marmelos Fruits -
2021.05
| 공동저자
| MOLECULES, 제26권 9호
Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway -
2021.01
| 공동저자
| PHARMACEUTICAL BIOLOGY, 제59권 1호, pp.74-86
Sauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Syk and IRAK1 -
2020.12
| 교신저자
| Natural Product Sciences, 제26권 4호, pp.289-294
A new coumestan glucoside from Eclipta prostrata -
2020.11
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제43권 21호, pp.4036-4046
Isolation of six anthraquinone diglucosides from cascara sagrada bark by high-performance countercurrent chromatography -
2020.09
| 교신저자
| Natural Product Sciences, 제26권 3호, pp.236-243
Isolation of phytochemicals from salvia plebeia using countercurrent chromatography coupled with reversed-phase HPLC -
2020.09
| 교신저자
| CARBOHYDRATE RESEARCH, 제495권
Kaempferol tri- and tetrasaccharides from Camellia japonica seed cake and their inhibitory activities against matrix metalloproteinase-1 secretion using human dermal fibroblasts -
2020.01
| 제1저자
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 제68권 3호, pp.742-750
In Vitro and in Vivo Anti-Hyperglycemic Activities of Taxifolin and Its Derivatives Isolated from Pigmented Rice (Oryzae sativa L. cv. Superhongmi) -
2020.01
| 교신저자
| JOURNAL OF GINSENG RESEARCH, 제44권 1호, pp.145-153
Identification of a novel triterpene saponin from Panax ginseng seeds, pseudoginsenoside RT8, and its antiinflammatory activity -
2020.01
| 교신저자
| 생약학회지, 제51권 1호, pp.78-85
HPLC method validation for quantitative analysis of scopoletin from hot-water extract powder of Artemisia annua linné -
2020.01
| 교신저자
| 생약학회지, 제51권 1호, pp.55-64
Phytochemical study of hot-water extract of Perillae Folium -
2019.11
| 공동저자
| NATURAL PRODUCT RESEARCH, 제33권 22호, pp.3317-3320
Anti-skin ageing effects of phenolic compounds from Carpinus tschonoskii -
2019.10
| 공동저자
| PSYCHIATRY INVESTIGATION, 제16권 10호, pp.759-765
An Exploration of the Oryza saliva L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment -
2019.06
| 공동저자
| NUTRIENTS, 제11권 6호
Water-Soluble Extract from Actinidia arguta (Siebold Zucc.) Planch. ex Miq. and Perilla frutescens (L.) Britton, ACTPER, Ameliorates a Dry Skin-Induced Itch in a Mice Model and Promotes Filaggrin Expression by Activating the AhR Signaling in HaCaT Cells -
2019.06
| 교신저자
| 생약학회지, 제50권 2호, pp.73-80
Phytochemical study of Adenophora stricta roots -
2019.05
| 교신저자
| MOLECULES, 제24권 9호
Phytochemical Study of Aerial Parts of Leea asiatica -
2019.04
| 교신저자
| PHYTOCHEMISTRY, 제160권, pp.11-18
Identification of fermented tea (Camellia sinensis) polyphenols and their inhibitory activities against amyloid-beta aggregation -
2019.03
| 교신저자
| PHYTOCHEMICAL ANALYSIS, 제30권 2호, pp.226-236
Separation of nine novel triterpene saponins from Camellia japonica seeds using high-performance countercurrent chromatography and reversed-phase high-performance liquid chromatography -
2018.12
| 교신저자
| Natural Product Sciences, 제24권 4호, pp.288-292
Efficient Isolation of Dihydrophaseic acid 3'-O-b-D-Glucopyranoside from Nelumbo nucifera Seeds Using High-performance Countercurrent Chromatography and Reverse-phased High-performance Liquid Chromatography -
2018.11
| 공동저자
| BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 제82권 11호, pp.1871-1879
Effect of Aurea Helianthus stem extract on anti-melanogenesis -
2018.11
| 공동저자
| KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 제22권 6호, pp.689-696
Cyanidin-3-glucoside inhibits amyloid 25-35-induced neuronal cell death in cultured rat hippocampal neurons -
2018.09
| 교신저자
| 생약학회지, 제49권 3호, pp.219-224
개똥쑥(Artemisia annua) 열탕추출물의 Di-caffeoylquinic Acid 및 Coumarin 성분 -
2018.07
| 공동저자
| FOOD AND CHEMICAL TOXICOLOGY, 제120권 1호, pp.651-661
Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions -
2018.05
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제41권 10호, pp.2169-2177
Application of off-line two-dimensional high-performance countercurrent chromatography on the chloroform-soluble extract of Cuscuta auralis seeds -
2018.04
| 공동저자
| EXPERIMENTAL NEUROBIOLOGY, 제27권 2호, pp.129-138
Black Rice (Oryza sativa L., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice -
2018.02
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제28권 3호, pp.476-481
Chemical constituents from Taraxacum officinale and their alpha-glucosidase inhibitory activities -
2017.12
| 교신저자
| Natural Product Sciences, 제23권 4호, pp.253-257
Chemical Constituents of Nelumbo nucifera Seeds -
2017.07
| 공동저자
| JOURNAL OF ETHNOPHARMACOLOGY, 제206권, pp.1-7
Src and Syk contribute to the anti-inflammatory activities of Achyranthes aspera ethanolic extract -
2016.11
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제0권 0호, pp.0-0
Efficient methods for isolating five phytochemicals from Gentiana macrophylla using high-performance countercurrent chromatography -
2016.09
| 공동저자
| TOXICOLOGY LETTERS, 제259권 1호, pp.1-10
In vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase (UGT) isoforms -
2016.09
| 공동저자
| EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 제118권 9호, pp.1416-1421
Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L. (Guttiferae) -
2016.01
| 제1저자
| BRITISH JOURNAL OF PHARMACOLOGY, 제173권 1호, pp.191-211
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase -
2015.10
| 교신저자
| PHYTOCHEMISTRY, 제118권, pp.17-22
Flavonoid glycosides from the aerial parts of Acacia pennata in Myanmar -
2015.07
| 교신저자
| MOLECULES, 제20권 7호, pp.13216-13225
Separation of polyphenols and caffeine from the acetone extract of fermented tea leaves (Camellia sinensis) using high-performance countercurrent chromatography -
2015.06
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제38권 11호, pp.1828-1836
Rapid separation of cyanidin-3-glucoside and cyanidin-3-rutinoside from crude mulberry extract using high-performance countercurrent chromatography and establishment of a volumetric scale-up process -
2015.06
| 공동저자
| JOURNAL OF ETHNOPHARMACOLOGY, 제168권, pp.217-228
In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract -
2015.06
| 공동저자
| JOURNAL OF FUNCTIONAL FOODS, 제17권 0호, pp.476-490
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6 -
2015.06
| 교신저자
| Natural Product Sciences, 제21권 2호, pp.76-81
Phenolic Compounds and Triterpenes from the Barks of Diospyros burmanica -
2015.05
| 제1저자
| JOURNAL OF SEPARATION SCIENCE, 제38권, pp.1872-1880
Development and validation of a liquid chromatography with tandem mass spectrometry method for the quantification of vitisin B in rat plasma and urine -
2015.03
| 교신저자
| Natural Product Sciences, 제21권 1호, pp.30-33
Rapid Isolation of Cyanidin 3-Glucoside and Peonidin 3-Glucoside from Black Rice (Oryza sativa) Using High-Performance Countercurrent Chromatography and Reversed-Phase Column Chromatography -
2015.03
| 교신저자
| Natural Product Sciences, 제21권 1호, pp.20-24
Isolation and Development of Quantification Method for Cyanidin-3-Glucoside and Cyanidin-3-Rutinoside in Mulberry Fruit by High-Performance Countercurrent Chromatography and High-Performance Liquid Chromatography -
2015.03
| 교신저자
| MOLECULES, 제20권, pp.4483-4491
Two New Phenolic Glucosides from Lagerstroemia speciosa -
2015.02
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제25권, pp.799-802
"Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs" -
2015.01
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제38권, pp.18-24
Application of high-performance countercurrent chromatography for the isolation of steroidal saponins from Liriope plathyphylla -
2015.01
| 교신저자
| MOLECULES, 제20권, pp.358-365
Flavonoids from Symplocos racemosa -
2014.12
| 공동저자
| XENOBIOTICA, 제44권 12호, pp.1099-1107
Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats -
2014.12
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제24권, pp.5644-5647
Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity -
2014.10
| 공동저자
| BIOLOGICAL & PHARMACEUTICAL BULLETIN, 제37권 10호, pp.1683-1688
Anti-adipogenic Constituents from Dioscorea opposita in 3T3-L1 Cells -
2014.10
| 공동저자
| FOOD AND CHEMICAL TOXICOLOGY, 제72권, pp.13-19
Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry; cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase -
2014.08
| 제1저자
| JOURNAL OF ETHNOPHARMACOLOGY, 제155권 1호, pp.185-193
Syk/Src-targeted anti-inflammatory activity of Codariocalyx motorius ethanolic extract -
2014.05
| 공동저자
| BIOLOGICAL & PHARMACEUTICAL BULLETIN, 제37권, pp.871-876
A Citrus Flavonoid, 6-Demethoxytangeretin, Suppresses Production and Gene Expression of Interleukin-6 in Human Mast Cell-1 via Anaplastic Lymphoma Kinase and Mitogen-Activated Protein Kinase Pathways -
2014.02
| 교신저자
| JOURNAL OF ETHNOPHARMACOLOGY, 제151권 3호, pp.1165-1174
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1 -
2014.02
| 공동저자
| JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 제29권, pp.1-6
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita) -
2013.12
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제36권, pp.3860-3865
Separation of five oligostilbenes from Vitis amurensis by flow-rate gradient high-performance counter-current chromatography -
2013.09
| 공동저자
| CHEMICO-BIOLOGICAL INTERACTIONS, 제205권 1호, pp.11-19
Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes -
2013.08
| 제1저자
| CURRENT DRUG TARGETS, 제14권, pp.999-1005
Enhanced Antioxidant and Protective Activities on Retinal Ganglion Cells of Carotenoids-Overexpressing Transgenic Carrot -
2013.07
| 공동저자
| JOURNAL OF SEPARATION SCIENCE, 제36권, pp.2306-2314
Direct measurement of active thiol metabolite levels of clopidogrel in human plasma using tris(2-carboxyethyl)phosphine as a reducing agent by LC-MS/MS -
2013.04
| 교신저자
| JOURNAL OF ETHNOPHARMACOLOGY, 제146권 3호, pp.873-880
Dipterocarpus tuberculatus ethanol extract strongly suppresses in vitro macrophage-mediated inflammatory responses and in vivo acute gastritis -
2013.02
| 공동저자
| BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 제34권 2호, pp.683-685
Novel Oxooxepane Derivatives and New Phorbic Acid Derivative from Paederia scandens -
2012.09
| 제1저자
| PHYTOCHEMICAL ANALYSIS, 제23권 5호, pp.462-468
Application of High-speed Countercurrent Chromatography-Evaporative Light Scattering Detection for the Separation of Seven Steroidal Saponins from Dioscorea villosa -
2012.09
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제00권 00호, pp.1-5
Quantitation and pharmacokinetics of 1,4-diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) butadiene (U0126) in rat plasma by liquid chromatography-tandem mass spectrometry -
2012.08
| 공동저자
| IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 제35권 1호, pp.8-14
Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages glycoside from Momordica cochinchinensis -
2012.07
| 제1저자
| PLOS ONE, 제7권 7호
A Novel Source of Methylglyoxal and Glyoxal in Retina: Implications for Age-Related Macular Degeneration -
2011.11
| 제1저자
| FOOD CHEMISTRY, 제129권 2호, pp.679-683
Separation of anti-ulcer flavonoids from Artemisia extracts by high-speed countercurrent chromatography -
2011.11
| 공동저자
| INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 제52권 12호, pp.9084-9090
A Novel Bisretinoid of Retina Is an Adduct on Glycerophosphoethanolamine -
2011.07
| 제1저자
| MOLECULAR VISION, 제17권 201호, pp.1839-1849
Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols -
2011.06
| 공동저자
| BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 제32권 6호, pp.2132-2134
Anti-inflammatory Constituents from the Roots of Saposhnikovia divaricata
-
2021.03
| 공동
| 신일서적
식물의약품과 생약 그리고 독성식물 -
2013.06
| 공동
| 신일북스
(생합성 경로를 중심으로 설명한) 천연의약품 -
2013.02
| 공동
| 東明社
생약학
-
2024.06.21
| 주발명자
| 주식회사 헬릭스미스,가톨릭대학교 산학협력단
2-Furoic acid를 포함하는 소양증의 예방, 개선 또는 치료용 조성물(Composition for prevention, alleviation or treatment of pruritus comprising 2-Furoic acid) -
2019.04.16
| 공동발명자
| 동국대학교 산학협력단, 가톨릭대학교 산학협력단
포도근 추출물 또는 이의 분획물을 유효성분으로 포함하는 C형 간염의 예방 또는 치료용 조성물 -
2016.04.27
| 공동발명자
| 가톨릭대학교 산학협력단
흑미추출물을 유효성분으로 함유하는 퇴행성 뇌질환 치료 및 예방용 조성물(A composition comprising the extract of black rice (Oryza sativa L.) for treating and preventing neuro-degenerative disease) -
2016.01.06
| 공동발명자
| 가톨릭대학교 산학협력단,동국대학교 산학협력단
C형 간염 바이러스의 게놈 복제의 선택적 저해 활성을 갖는 레스베라트롤 다량체 및 이의 용도(Resveratrol multimers with selective inhibitory of genome replication of HCV and use thereof) -
2014.12.16
| 공동발명자
| 가톨릭대학교 산학협력단,동국대학교 산학협력단
포도근 추출물 또는 이의 분획물을 유효성분으로 포함하는 C형 간염의 예방 또는 치료용 조성물(Composition for the prevention or treatment of Hepatitis C, comprising extracts or fractions of Vitidis Vinferae Radix as an effective ingredient) -
2011.11.01
| 공동발명자
| 서울대학교산학협력단
쑥속식물의 추출물로부터 원심향류분배 크로마토그래피를 이용한 고농도 유파티린 및 자세오시딘（Ｊａｃｅｏｓｉｄｉｎｅ）을 대량으로 분리 및생산하는 방법(A method for isolating and producing highly-concentrated Eupatilin and Jaceosidine from the extract of Artemisia species by using Centrifugal Partition Chromatography)