강한창 교수
KANG, HAN CHANG
- 02-2164-6533
- hckang@catholic.ac.kr
- 정진석추기경약학관 NP516
연구분야
약제학/물리약학
연구키워드
약물전달/나노의약
교수소개
유전자, 단백질, 화학약물 등을 세포 표적, 세포소기관 표적, 시그널링분자 표적, 수송체/수용체 표적 나노약물전달체를 이용하여 표적질환을 효과적으로 치료할 수 있는 약물전달기술 및 나노의약품을 설계 및 개발하는 연구를 수행하고 있으며, 연구 결과를 약 110편의 Journal Article, 32건의 국내외 등록특허, Book chapter 4편을 통해 발표했습니다. 또한, 현재 Acta Pharmaceutica Sinica B, NanoConvergene에서 editorial board member로, Journal of Pharmaceutical Investigation, Journal of the Korean Chemical Society에서 Associate Editor로 활동하고 있습니다.
Han Chang Kang is a professor of pharmacy at The Catholic University of Korea (CUK) in the Republic of Korea. He received his Ph.D. in Pharmaceutics and Pharmaceutical Chemistry at the University of Utah (UU; Salt Lake City, Utah, USA). After completing his degree, he worked as a post-doctoral fellow and a research assistant professor at UU. In 2011, he joined the College of Pharmacy, CUK, as a full-time instructor and now works as a professor. He is also an associate editor or editorial board member in Acta Pharmaceutica Sinica B, NanoConvergence, Journal of Pharmaceutical Investigation, and Journal of the Korean Chemical Society. His research interest is drug delivery and nanomedicine, mainly focusing on designing and developing cell/organelle/signaling molecule/transporting molecule-targeted nanoscale systems for delivering genes, proteins, and chemicals.
최종학력
2007.12.15 | 유타대학교 | 약제학 및 약제화학과 | 약제학 박사
연구실적
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2024.09
| 교신저자
| ADVANCED DRUG DELIVERY REVIEWS, 제212권
Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond -
2024.07
| 교신저자
| MACROMOLECULAR BIOSCIENCE, 제24권 7호
Beyond Nanoparticle-Based Intracellular Drug Delivery: Cytosol/Organelle-Targeted Drug Release and Therapeutic Synergism -
2024.06
| 교신저자
| BIOMATERIALS SCIENCE, 제12권 12호, pp.3045-3067
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting -
2024.04
| 공동저자
| SCIENTIFIC REPORTS, 제14권 1호
Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis -
2024.04
| 공동저자
| CELL DEATH & DISEASE, 제15권 4호
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance -
2024.03
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제56권 3호, pp.686-699
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death -
2024.02
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제47권 2호, pp.111-126
Comparative metabolism of aschantin in human and animal hepatocytes -
2024.01
| 공동저자
| TOXICOLOGICAL RESEARCH, 제40권 1호, pp.125-137
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes -
2023.09
| 공동저자
| ACTA PHARMACEUTICA SINICA B, 제13권 9호, pp.3834-3848
Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier -
2023.09
| 공동저자
| FOOD AND CHEMICAL TOXICOLOGY, 제179권
Toxicokinetics and tissue distribution of phalloidin in mice -
2023.06
| 공동저자
| BIOMEDICINE & PHARMACOTHERAPY, 제162권
Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression -
2023.06
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제46권 6호, pp.500-534
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases -
2023.05
| 공동저자
| ADVANCED MATERIALS, 제35권 18호
Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy -
2023.02
| 공동저자
| JOURNAL OF CONTROLLED RELEASE, 제354권, pp.651-663
Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy -
2023.01
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제46권 1호, pp.44-58
MEKs/ERKs-mediated FBXO1/E2Fs interaction interference modulates G(1)/S cell cycle transition and cancer cell proliferation -
2023.01
| 교신저자
| CHEMICAL ENGINEERING JOURNAL, 제456권
e-Poly(L-lysine)-based bioreducible nanogels for mitochondria-targeted delivery and release: Hydrophobicity-tuned nucleus-to-mitochondria organelle-targeting switch and slow disulfide cleavage -
2022.10
| 공동저자
| FRONTIERS IN MOLECULAR BIOSCIENCES, 제9권
Inflammasomes and their roles in arthritic disease pathogenesis -
2022.09
| 공동저자
| BIOMOLECULES & THERAPEUTICS
Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation -
2022.08
| 공동저자
| THERANOSTICS, 제12권 13호, pp.5856-5876
Nanogel-mediated delivery of oncomodulin secreted from regeneration-associated macrophages promotes sensory axon regeneration in the spinal cord -
2022.05
| 공동저자
| BIOMATERIALS SCIENCE, 제10권 11호, pp.2817-2830
Extracellular vesicles with high dual drug loading for safe and efficient combination chemo-phototherapy -
2022.04
| 공동저자
| PHARMACEUTICS, 제14권 4호
Toxicokinetics of β-Amanitin in Mice and In Vitro Drug–Drug Interaction Potential -
2022.01
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제54권 1호, pp.35-46
FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells -
2022.01
| 교신저자
| BIOMATERIALS, 제280권
Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability -
2021.12
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells -
2021.11
| 공동저자
| PHARMACEUTICALS, 제14권 11호
Rig-i deficiency promotes obesity-induced insulin resistance -
2021.11
| 공동저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 제84권 22호, pp.922-931
Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells -
2021.10
| 공동저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 제84권 20호, pp.821-835
Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug–drug interaction potentials -
2021.09
| 공동저자
| 대한암예방학회지, 제26권 3호, pp.174-182
F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2 -
2021.06
| 공동저자
| ACS APPLIED MATERIALS & INTERFACES, 제13권 22호, pp.25575-25588
Safe and Targeted Sonodynamic Cancer Therapy Using Biocompatible Exosome-Based Nanosonosensitizers -
2021.03
| 공동저자
| CELLS, 제10권 3호
Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy -
2021.02
| 교신저자
| ADVANCED FUNCTIONAL MATERIALS, 제31권 6호
Disrupting the Redox Balance with a Diselenide Drug Delivery System: Synergistic or Antagonistic? -
2021.02
| 공동저자
| PHARMACEUTICS, 제13권 2호
Tetrahydrofurofuranoid lignans, eudesmin, fargesin, epimagnolin a, magnolin, and yangambin inhibit UDP-glucuronosyltransferase 1A1 and 1A3 activities in human liver microsomes -
2021.02
| 공동저자
| FRONTIERS IN IMMUNOLOGY, 제11권
Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules -
2021.02
| 공동저자
| MOLECULES, 제26권 4호
Loganin alleviates gout in ammation by suppressing NLRP3 in ammasome activation and mitochondrial damage -
2021.02
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제22권 4호, pp.1-18
Fargesin inhibits egf-induced cell transformation and colon cancer cell growth by suppression of CDK2/cyclin E signaling pathway -
2021.01
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제44권 1호, pp.16-35
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases -
2020.11
| 공동저자
| PHARMACEUTICS, 제12권 11호, pp.1-18
Inhibitory effect of AB-PINACA, indazole carboxamide synthetic cannabinoid, on human major drug-metabolizing enzymes and transporters -
2020.09
| 공동저자
| BIOMOLECULES & THERAPEUTICS, 제28권 5호, pp.437-442
Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome -
2020.09
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제52권 9호, pp.1526-1536
Stat2 stability regulation: an intersection between immunity and carcinogenesis -
2020.08
| 교신저자
| BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 제1866권 8호
Mitochondria-targeted drug delivery in cancers -
2020.08
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제88권, pp.260-267
Non-ionic polysorbate-based nanoparticles for efficient combination chemo/photothermal/photodynamic therapy -
2020.07
| 공동저자
| ARTHRITIS & RHEUMATOLOGY, 제72권 7호, pp.1192-1202
Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis -
2020.06
| 교신저자
| PHARMACEUTICS, 제12권 6호
Effects of Decomplexation Rates on Ternary Gene Complex Transfection with alpha-Poly(L-Lysine) or epsilon-Poly(L-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell -
2020.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제21권 8호
Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome -
2020.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제21권 8호
Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis -
2020.03
| 공동저자
| MOLECULES, 제25권 5호
Liquid chromatography-tandem mass spectrometry for the simultaneous determination of doxorubicin and its metabolites doxorubicinol, doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone in mouse plasma -
2020.01
| 공동저자
| PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 제117권 1호, pp.584-594
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation -
2019.12
| 교신저자
| POLYMERS FOR ADVANCED TECHNOLOGIES, 제30권 12호, pp.2993-3002
Reduction-responsive poly(ethylene glycol)-dexamethasone biarm conjugate and its self-assembled nanomicelles: preparation, physico-chemical characterization, and thiol-triggered drug release -
2019.12
| 교신저자
| COLLOIDS AND SURFACES B-BIOINTERFACES, 제184권
Controlling complexation/decomplexation and sizes of polymer-based electrostatic pDNA polyplexes is one of the key factors in effective transfection -
2019.08
| 공동저자
| SCIENTIFIC REPORTS, 제9권
Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells -
2019.08
| 공동저자
| MOLECULES, 제24권 16호
In vitro inhibitory effects of APINACA on human major cytochrome P450, UDP-glucuronosyltransferase enzymes, and drug transporters -
2019.07
| 공동저자
| PHARMACEUTICS, 제11권 7호
Identification of catalposide metabolites in human liver and intestinal preparations and characterization of the relevant sulfotransferase, UDP-glucuronosyltransferase, and carboxylesterase enzymes -
2019.07
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제75권, pp.238-245
ROS-responsive thioether-based nanocarriers for efficient pro-oxidant cancer therapy -
2019.07
| 공동저자
| MOLECULAR CARCINOGENESIS, 제58권 7호, pp.1221-1233
Epimagnolin targeting on an active pocket of mammalian target of rapamycin suppressed cell transformation and colony growth of lung cancer cells -
2019.06
| 공동저자
| MOLECULES, 제24권 11호
Epigallocatechin-3-gallate prevents acute gout by suppressing NLRP3 inflammasome activation and mitochondrial DNA synthesis -
2019.05
| 공동저자
| WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 제11권 3호
Targeted siRNA delivery using aptamer-siRNA chimeras and aptamer-conjugated nanoparticles -
2019.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제20권 8호
RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity -
2019.02
| 공동저자
| MOLECULES, 제24권 4호
In Vitro Metabolism of 25B-NBF, 2-(4-Bromo-2, 5-Dimethoxyphenyl)-N-(2-Fluorobenzyl)ethanamine, in Human Hepatocytes Using Liquid Chromatography–Mass Spectrometry -
2019.01
| 공동저자
| MOLECULAR CARCINOGENESIS, 제58권 1호, pp.88-101
Magnolin targeting of ERK1/2 inhibits cell proliferation and colony growth by induction of cellular senescence in ovarian cancer cells -
2018.12
| 공동저자
| PHYTOTHERAPY RESEARCH, 제32권 12호, pp.2551-2559
Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome -
2018.11
| 단독
| BIOMATERIALS RESEARCH, 제22권 1호
Mitochondria-targeting theranostics -
2018.10
| 공동저자
| ADVANCED FUNCTIONAL MATERIALS, 제28권 40호, pp.201801918-201801918
Efficient Transdermal Delivery of DNA Nanostructures Alleviates Atopic Dermatitis Symptoms in NC/Nga Mice -
2018.10
| 교신저자
| ACTA PHARMACEUTICA SINICA B, 제8권 6호, pp.862-880
Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives -
2018.08
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제64권, pp.300-310
Dual-functionalized calcium nanocomplexes for transfection of cancerous and stem cells: Low molecular weight polycation-mediated colloidal stability and ATP-mediated endosomal release -
2018.08
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1092권, pp.114-121
Simultaneous quantification of 18 saturated and unsaturated fatty acids and 7 sterols as their tert-butyldimethylsilyl derivatives in human saliva using gas chromatography-tandem mass spectrometry -
2018.08
| 교신저자
| FRONTIERS IN PHARMACOLOGY, 제9권
Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment -
2018.07
| 교신저자
| BIOMACROMOLECULES, 제19권 7호, pp.2483-2495
Effects of the Physicochemical, Colloidal, and Biological Characteristics of Different Polymer Structures between α-Poly(l -lysine) and ϵ-Poly(l -lysine) on Polymeric Gene Delivery -
2018.07
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제63권, pp.57-64
Cancer-specific pro-oxidant therapy using low-toxic polypeptide micelles encapsulating piperlongumine -
2018.04
| 공동저자
| RHEUMATOLOGY, 제57권 4호, pp.727-736
Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation -
2018.04
| 공동저자
| INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 제110권 Special SI호, pp.366-374
Synthesis and characterization of bioreducible cationic biarm polymer for efficient gene delivery -
2018.03
| 공동저자
| CELL DEATH & DISEASE, 제9권 3호, pp.401-401
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis -
2018.08
| 공동저자
| DRUG TESTING AND ANALYSIS, 제10권 8호, pp.1328-1335
Targeted and non-targeted metabolite identification of MAM-2201 in human, mouse, and rat hepatocytes -
2017.11
| 교신저자
| MICROPOROUS AND MESOPOROUS MATERIALS, 제253권, pp.96-101
Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper -
2017.04
| 교신저자
| BIOMACROMOLECULES, 제18권 4호, pp.1074-1085
Bioreducible Poly(ethylene glycol)-Triphenylphosphonium Conjugate as a Bioactivable Mitochondria-Targeting Nanocarrier -
2017.03
| 교신저자
| MOLECULAR PHARMACEUTICS, 제14권 3호, pp.842-855
Tempo-spatial Activation of Sequential Quadruple Stimuli for High Gene Expression of Polymeric Gene Nanocomplexes -
2017.03
| 교신저자
| INTERNATIONAL JOURNAL OF PHARMACEUTICS, 제520권 1-2호, pp.195-206
Photosensitizer-mediated mitochondria-targeting nanosized drug carriers: Subcellular targeting, therapeutic, and imaging potentials -
2016.09
| 교신저자
| ACTA BIOMATERIALIA, 제41권, pp.147-160
Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction -
2016.02
| 교신저자
| RSC ADVANCES, 제6권 19호, pp.15558-15576
Intracellular thiol-responsive nanosized drug carriers self-assembled by poly(ethylene glycol)-b-poly(epsilon-caprolactone)-b-poly(ethylene glycol) having multiple bioreducible disulfide linkages in hydrophobic blocks -
2016.01
| 공동저자
| POLYMER-KOREA, 제40권 1호, pp.54-62
Synthesis and Characterization of Poly(ethylene glycol)/Poly(trimethylene carbonate) AB(2) Miktoarm Copolymers for Anticancer Drug Delivery -
2015.10
| 교신저자
| JOURNAL OF CONTROLLED RELEASE, 제216권 0호, pp.30-36
Synthetic polynucleotides as endosomolytic agents and bioenergy sources -
2015.09
| 교신저자
| ADVANCED FUNCTIONAL MATERIALS, 제25권 34호, pp.5479-5491
Triphenylphosphonium-Conjugated Poly(ε-caprolactone)-Based Self-Assembled Nanostructures as Nanosized Drugs and Drug Delivery Carriers for Mitochondria-Targeting Synergistic Anticancer Drug Delivery -
2015.08
| 제1저자
| MOLECULAR PHARMACEUTICS, 제12권 8호, pp.2845-2857
DNA Polyplexes as Combination Drug Carriers of Doxorubicin and Cisplatin: An In Vitro Study -
2015.05
| 공동저자
| CARBOHYDRATE POLYMERS, 제121권 0호, pp.122-131
Polyelectrolyte nanocomplex formation of heparin-photosensitizer conjugate with polymeric scavenger for photodynamic therapy -
2015.01
| 제1저자
| POLYMER CHEMISTRY, 제6권 4호, pp.531-542
Amphiphilic poly(ethylene glycol)-poly(ε-caprolactone) AB2 miktoarm copolymers for self-assembled nanocarrier systems: Synthesis, characterization, and effects of morphology on antitumor activity -
2014.10
| 교신저자
| MACROMOLECULAR BIOSCIENCE, 제14권 10호, pp.1483-1494
Bioreducible branched polyethyleneimine derivatives physically loaded with hydrophobic pheophorbide A: Preparation, characterization, and light-induced cytotoxicity -
2014.09
| 공동저자
| PLOS ONE, 제9권 9호
The Sensitivity of Cancer Cells to Pheophorbide a-Based Photodynamic Therapy Is Enhanced by NRF2 Silencing -
2014.08
| 교신저자
| INTERNATIONAL JOURNAL OF PHARMACEUTICS, 제471권 1-2호, pp.339-348
Antioxidant-photosensitizer dual-loaded polymeric micelles with controllable production of reactive oxygen species -
2014.07
| 교신저자
| ADVANCED HEALTHCARE MATERIALS, 제3권 7호, pp.1007-1014
Nucleotides as nontoxic endogenous endosomolytic agents in drug delivery -
2014.06
| 교신저자
| BIOMACROMOLECULES, 제15권 6호, pp.2224-2234
Biarmed poly(ethylene glycol)-(pheophorbide a)2 conjugate as a bioactivatable delivery carrier for photodynamic therapy -
2014.06
| 제1저자
| MACROMOLECULAR BIOSCIENCE, 제14권 6호, pp.831-841
Dexamethasone-loaded reconstitutable charged polymeric (PLGA) n-b-bPEI micelles for enhanced nuclear delivery of gene therapeutics -
2014.05
| 공동저자
| POLYMERS FOR ADVANCED TECHNOLOGIES, 제25권 5호, pp.545-551
Bioreducible polyspermine as less toxic and efficient gene carrier -
2014.04
| 제1저자
| COLLOIDS AND SURFACES B-BIOINTERFACES, 제116권 0호, pp.128-137
Effects of cholesterol incorporation on the physicochemical, colloidal, and biological characteristics of pH-sensitive AB2 miktoarm polymer-based polymersomes -
2013.08
| 제1저자
| BIOMACROMOLECULES, 제14권 8호, pp.2570-2581
Endosomolytic reducible polymeric electrolytes for cytosolic protein delivery -
2013.07
| 공동저자
| JOURNAL OF SEPARATION SCIENCE, 제36권, pp.2306-2314
Direct measurement of active thiol metabolite levels of clopidogrel in human plasma using tris(2-carboxyethyl)phosphine as a reducing agent by LC-MS/MS -
2013.02
| 제1저자
| BIOMACROMOLECULES, 제14권 2호, pp.548-556
Bioreducible polymers as a determining factor for polyplex decomplexation rate and transfection -
2012.12
| 제1저자
| JOURNAL OF CONTROLLED RELEASE, 제164권 3호, pp.256-264
Polymeric nucleic acid carriers: Current issues and novel design approaches -
2012.12
| 공동저자
| BIOMATERIALS, 제33권 34호, pp.8848-8857
Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere -
2012.09
| 제1저자
| JOURNAL OF MATERIALS CHEMISTRY, 제22권 36호, pp.19168-19178
Biocompatible, pH-sensitive AB(2) miktoarm polymer-based polymersomes: preparation, characterization, and acidic pH-activated nanostructural transformation -
2012.09
| 제1저자
| BIOMACROMOLECULES, 제13권 9호, pp.2945-2951
pH-Sensitive Polymeric Micelle-Based pH Probe for Detecting and Imaging Acidic Biological Environments -
2012.06
| 제1저자
| JOURNAL OF CONTROLLED RELEASE, 제160권 3호, pp.440-450
Nanoscaled buffering zone of charged (PLGA)(n)-b-bPEI micelles in acidic microclimate for potential protein delivery application -
2012.03
| 공동저자
| MACROMOLECULAR RESEARCH, 제20권, pp.224-233
pH-sensitive polymers for drug delivery -
2012.02
| 제1저자
| BIOMATERIALS, 제33권 5호, pp.1651-1662
The effect of environmental pH on polymeric transfection efficiency -
2011.07
| 제1저자
| BIOMATERIALS, 제32권 21호, pp.4914-4924
Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide -
2011.05
| 제1저자
| BIOMATERIALS, 제32권 15호, pp.3845-3854
Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery -
2011.02
| 제1저자
| BIOMATERIALS, 제32권 4호, pp.1193-1203
A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane -
2010.04
| 제1저자
| BIOMATERIALS, 제31권, pp.3071-3078
Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells -
2009.05
| 제1저자
| BIOMATERIALS, 제30권 14호, pp.2837-2845
Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector -
2009.07
| 제1저자
| DIABETES TECHNOLOGY & THERAPEUTICS, 제11권 7호, pp.443-449
Transfection of Rat Pancreatic Islet Tissue by Polymeric Gene Vectors -
2009.05
| 공동저자
| BIOMATERIALS, 제30권, pp.2642-2652
All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control -
2008.11
| 공동저자
| POLYMERS FOR ADVANCED TECHNOLOGIES, 제19권 11호, pp.1558-1565
Synthesis of poly(cystine bisamide)-PEG block copolymers grafted with 1-(3-aminopropyl)imidazole and their phase transition behaviors -
2007.05
| 제1저자
| ADVANCED FUNCTIONAL MATERIALS, 제17권 8호, pp.1263-1272
pH-tunable endosomolytic oligomers for enhanced nucleic acid delivery -
2006.08
| 제1저자
| PHARMACEUTICAL RESEARCH, 제23권 8호, pp.1797-1808
Polymeric gene transfection on insulin-secreting cells: Sulfonylurea receptor-mediation and transfection medium effect -
2005.12
| 제1저자
| CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 제15권, pp.317-342
Polymeric gene carriers -
2005.06
| 제1저자
| JOURNAL OF CONTROLLED RELEASE, 제105권, pp.164-176
Polymeric gene carrier for insulin secreting cells: Poly(L-lysine)-g-sulfonylurea for receptor mediated transfection -
2002.03
| 제1저자
| , 제10권, pp.67-74
Preparation and characterization of new immunoprotecting membrane coated with amphiphilic multiblock copolymer -
2000.08
| 제1저자
| , 제41권, pp.6931-6934
Enhanced electrical conductivity of polypyrrole prepared by chemical oxidative polymerization: effect of the preparation technique and polymer additive
-
2015.04
| 공동
| CRC Press
Encyclopedia on Biomedical Polymers and Polymeric Biomaterials -
2014.06
| 공동
| 신일서적
물리약학 요약집 -
2013.02
| 공동
| 신일북스
(마틴의) 물리약학 -
2010.11
| 공동
| Wiley
Organelle-specific pharmaceutical nanotechnology. Chapter 14 (pp. 247-262). Endolysosomolytically active pH-sensitive polymeric nanotechnology -
2008.03.21
| 공동
| Springer
Multifunctional Pharmaceutical Nanocarriers, Chapter 6 (page 161-199), Stimuli-sensitive Nanosystems: For Drug and Gene Delivery -
2007.03
| 공동
| Horizon Bioscience
Nanotechnology in Therapeutics: Current Technology and Applications. Chapter 6 (pp. 131-161) Polymeric Gene Delivery Vectors
-
2022.07.21
| 공동발명자
| 가톨릭대학교 산학협력단
분지형 DNA 덴드리머 및 환원성 양이온 중합체로 구성된 복합체, 및 상기 복합체를 포함하는 면역 증진용 조성물(A complex consisting of branched DNA dendrimer and reducible polycations, and a composition comprising the complex for enhancing immunity) -
2021.09.02
| 주발명자
| 가톨릭대학교 산학협력단
엔도솜 분해능 및 환원 분해성을 갖는 입실론-폴리(엘-라이신) 고분자 나노겔, 이의 제조방법 및 용도(ε-poly(L-lysine) polymer nanogel which has endosomolytic activity and reductive degradability, Its synthesis, and Use thereof) -
2020.10.27
| 주발명자
| 가톨릭대학교 산학협력단
엽산 수용체 표적능 및 엔도솜막 분해능을 갖는 엽산-폴리(입실론-카프로락톤)-엽산 고분자 및 이의 용도(folic acid-poly(ε-caprolactone)-folic acid which has folate receptor targeting and endosomolytic activity, and use thereof) -
2020.04.17
| 주발명자
| 가톨릭대학교 산학협력단
미토콘드리아 표적능을 갖는 고분자 및 상기 고분자를 이용한 약물 전달용 조성물(Polymer having mitochondrial targeting ability and composition for drug delivery using the polymer) -
2019.10.17
| 주발명자
| 가톨릭대학교 산학협력단
사이티딘 5-삼인산 또는 이의 고분자를 유효성분으로 포함하는 핵 내로의 약물 전달용 조성물 및 면역 증강제(Composition for Drug Delivery into Nucleus Comprising Cytidine 5-triphosphate or Polymer thereof, and Immunostimulating Agents Comprising the Same) -
2019.07.19
| 주발명자
| 가톨릭대학교 산학협력단
엔도솜 분해능과 핵 내 전달능을 갖는 아스코르브산 2-인산(ascorbic acid 2-phosphate)과 이의 고분자 및 이들의 용도(Ascorbic acid 2-phosphate, Its polymers having endosomolytic activity and nuclear delivery activity, and Use thereof) -
2019.07.19
| 주발명자
| 가톨릭대학교 산학협력단
엔도솜 분해능과 핵 내 전달능을 갖는 폴리(피리독살 5-인산)[poly(pyridoxal 5-phosphate)] 고분자, 이의 제조방법 및 용도(Poly(Pyridoxal 5-phosphate) which has endosomolytic activity and nuclear delivery activity, Its synthesis, and Use thereof) -
2019.06.18
| 주발명자
| 가톨릭대학교 산학협력단
디셀레노디프로피오네이트의 양 말단에 폴리(입실론-카프로락톤)이 공유결합된 환원분해성 폴리(입실론-카프로락톤) 고분자, 이를 포함하는 항암용 조성물 및 약물 전달용 조성물 -
2019.05.21
| 주발명자
| 가톨릭대학교 산학협력단
석시네이트-폴리(입실론-카프로락톤)-석시네이트 고분자, 상기 고분자를 이용한 자기조립 나노입자 및 이를 포함하는 조성물(Succinate-poly(ε-caprolactone)-succinate Polymers, Self-assembled Drug Delivery Nanoparticles Made thereby, and Composition Comprising the Same) -
2019.03.05
| 주발명자
| 가톨릭대학교 산학협력단, 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소
Reducing or non-reducing polynucleotide polymer for drug delivery and method for preparing same -
2018.12.11
| 주발명자
| 가톨릭대학교 산학협력단
양 말단에 친수성 카르복실기를 갖는 환원분해성 폴리(입실론-카프로락톤) 고분자 및 상기 고분자를 이용한 약물 전달용 조성물(Reductive degradable poly(ε-caprolactone) polymer with hydrophilic carboxyl group at both ends and drug delivery composition using the same) -
2018.09.11
| 주발명자
| 가톨릭대학교 산학협력단,재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소
약물 전달용 환원성 또는 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법 -
2017.11.15
| 주발명자
| 가톨릭대학교 산학협력단,재단법인 유타인하 디디에스 및 신의료기술개발 공동연구소
약물 전달용 환원성 또는 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법 -
2017.05.12
| 주발명자
| 가톨릭대학교 산학협력단,재단법인 유타인하디디에스 및 신의료기술개발 공동연구소
약물전달용 환원성 또는 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조 방법 -
2016.03.18
| 주발명자
| 가톨릭대학교 산학협력단,재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소
mPEG-b-RSPCL-b-mPEG 블록공중합체 및 상기 블록공중합체를 이용한 나노약물전달용 조성물(PEG-b-RSPCL-b-PEG block copolymer and nano-drug delivery composition using the same) -
2015.12.18
| 주발명자
| 가톨릭대학교(70),재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소(30)
TPP-PCL-TPP 고분자 및 상기 고분자를 이용한 미토콘드리아 표적 나노 약물 전달용 조성물 -
2015.12.08
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
소수성 광역학 약물이 봉입된 친수성 양전하성 고분자 복합체의 제조방법 및 상기 고분자 복합체를 이용한 약물전달체(Preparation method of hydrophobic photodynamic chemicals solubilized hydrophilic positively-charged polymers and drug delivery systems using the same) -
2015.12.08
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
칼슘 이온 및 인산기를 가진 친수성 뉴클레오타이드 또는 이의 유사체를 이용한 나노복합체의 제조방법 및 상기 나노복합체를 이용한 약물전달체(Preparation method of nanocomplex with calcium ion and phosphate-containing hydrophilic nucleotides or analogues thereof and drug delivery systems using the same) -
2015.12.08
| 주발명자
| 가톨릭대학교(70),재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소(30)
엔도솜 분해능을 갖는 뉴클레오타이드 및 이의 용도 -
2015.12.08
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
칼슘 이온 및 친수성 비스포스포네이트를 이용한 나노복합체의 제조방법 및 상기 나노복합체를 이용한 약물전달체(Preparation method of nanocomplex with calcium ion and hydrophilic bisphosphonates and drug delivery systems using the same) -
2015.11.03
| 주발명자
| 가톨릭대학교 산학협력단
칼슘 이온 및 친수성 음이온성 광민감제를 이용한 나노복합체의 제조방법 및 상기 나노복합체를 이용한 약물전달체(Preparation method of nanocomplex with calcium ion and hydrophilic anionic photosensitizer and drug delivery systems using the same) -
2015.08.20
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
비환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물(Composition for non-viral drug delivery comprising non-reducible polynucleotide polymer) -
2015.08.20
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
약물 전달용 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법(Non-reducible polynucleotide polymer for drug delivery and method for preparing the same) -
2015.08.20
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물(Composition for non-viral drug delivery comprising reducible polynucleotide polymer) -
2015.08.20
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
약물 전달용 환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법(Reducible polynucleotide polymer for drug delivery and method for preparing the same) -
2015.07.20
| 주발명자
| 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소,가톨릭대학교 산학협력단
엔도솜 분해능을 갖는 뉴클레오타이드 및 이의 용도(Nucleotide having endosomolysis activity and uses thereof)
-
2020.03.06
| 주발명자
| 파마티브 주식회사
‘엔도솜 분해능 및 환원 분해성을 갖는 입실론-폴리(엘-라이신) 고분자 나노겔, 이의 제조방법 및 용도’의 기술이전 건 -
2018.10.11
| 주발명자
| ㈜파마티브
‘엔도솜 분해능과 핵 내 전달능을 갖는 폴리(피리독살 5-인산)고분자, 이의 제조방법 및 용도’의 기술이전 건