서재홍 교수
Seo, Jae Hong
- 02-2164-6531
- jaehongseo@catholic.ac.kr
- 정진석추기경약학관 NP317
연구분야
헤테로고리 화합물 합성에 유용한 신규 촉매 반응 개발 및 의약화학적 응용
연구키워드
유기화학
의약화학
촉매 반응
교수소개
본인은 2008년 펜실베니아 주립대(PSU)에서 천연물 전합성 연구로 박사 학위를 받았고, KIST(1995~2002)와 Scripps연구소(2008~2011)에서 의약화학 및 천연물 전합성 연구를 10년 이상 진행한 바 있다. 2011년 가톨릭대에 임용된 이후에는 팔라듐 촉매를 이용한 신규 합성 방법 개발 연구를 주로 하고 있다. 특히 초기 신약개발 단계에서 필요한 다양한 저분자 물질 확보에 유용한 다양성 지향 합성 개념에 충실하도록 다단계 반응을 묶어서 한번의 반응으로 가능하게 하는 직렬 반응 연구에 중점을 두고 있다. 개발된 합성 방법을 활용하여 확보된 헤테로 고리 화합물들은 실제 생리활성 시험을 통해 SERM, IL6 활성 저해 후보 물질로 의약화학적 후속 연구를 진행하고 있으며, 직렬 반응을 이용한 효율적 천연물 전합성 연구도 함께 진행하고 있다.
In 2008, I received Ph. D. degree from Pennsylvania State University (PSU) with research about total synthesis of natural product. Also I have worked several institutes, such as KIST (Korea Institute of Science & Technology: 1995~2002) and TSRI (The Scripps Research Institute: 2008~2011), where I performed research related with various new drug development projects and total synthesis of complex natural products. Since starting independent research career at The Catholic University of Korea (CUK) in 2011, I have mainly focused on the research of novel synthetic method development utilizing palladium-catalyzed reaction. Especially, I interested in tandem and/or one-pot reactions, which converts multi-step reactions into a single reaction. These types of reactions have the advantage of facilitating the approach to various heterocyclic compounds, which is needed for early stage of new drug development research. The compounds obtained from methodolgy research have been tested for biological activities and utilized in subsequent medicinal chemistry research, such as for SERMs and IL6 inhibitors. Total synthesis of natural products has also been studied and recently finished synthesis of cyclopiamide A.
최종학력
2008.12.20 | 펜실베니아 주립대 | 화학과 | 박사
연구실적
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2022.08
| 교신저자
| MOLECULES, 제27권 16호
Non-Palladium-Catalyzed Approach to the Synthesis of (E)-3-(1,3-Diarylallylidene)Oxindoles -
2020.12
| 교신저자
| HETEROCYCLES, 제100권 12호, pp.2050-2060
Stereoselective Synthesis of (Z)-3-Arylidene-2-oxindoles via a Palladium-Catalyzed Tandem Reaction -
2020.11
| 교신저자
| MOLECULES, 제25권 21호
Total Synthesis of Cyclopiamide A Using Palladium-Catalyzed Domino Cyclization -
2018.12
| 교신저자
| HETEROCYCLES, 제96권 10호, pp.1795-1807
Palladium-Catalyzed One-Pot Approach to 3-(1,3-Diarylprop-2-ylidene)oxindoles -
2018.08
| 제1저자
| BRITISH JOURNAL OF PHARMACOLOGY, 제175권 16호, pp.3347-3360
The phosphodiesterase 5 inhibitor, KJH-1002, reverses a mouse model of amnesia by activating a cGMP/cAMP response element binding protein pathway and decreasing oxidative damage -
2017.03
| 교신저자
| MOLECULES, 제22권 3호
Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles -
2017.02
| 교신저자
| JOURNAL OF ORGANIC CHEMISTRY, 제82권 3호, pp.1864-1871
Stereoselective Synthesis of 3-(1,3-Diarylallylidene)oxindoles via a Palladium-Catalyzed Tandem Reaction -
2017.01
| 공동저자
| SYNLETT, 제28권 2호, pp.249-252
Total Synthesis of (±)-Decytospolides A and B -
2016.10
| 공동저자
| DRUG DESIGN DEVELOPMENT AND THERAPY, 제10권 1호, pp.2959-2972
Application of physiologically based pharmacokinetic modeling in predicting drug-drug interactions for sarpogrelate hydrochloride in humans -
2016.09
| 교신저자
| MOLECULES, 제21권 9호
Aspirination of -Aminoalcohol (Sarpogrelate M1) -
2016.02
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제26권 4호, pp.1120-1123
Identification and characterization of potent, selective and metabolically stable IKK beta inhibitor -
2016.02
| 교신저자
| ASIAN JOURNAL OF ORGANIC CHEMISTRY, 제5권 2호, pp.287-292
Hendrickson-Reagent-Mediated Conversion of N-Boc Carbamates to Isocyanates: Applications for the Synthesis of 3,4-Dihydroisoquinolin-1-ones and Ureas -
2015.10
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제25권 20호, pp.4481-4486
Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent -
2015.10
| 교신저자
| SYNLETT, 제26권 16호, pp.2296-2300
Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)-oxindoles Using Microwave Irradiation -
2015.08
| 제1저자
| Bulletin of the Korean Chemical Society, 제36권 8호, pp.1957-1958
Concise and scalable synthesis of xanthylentin -
2015.08
| 교신저자
| MOLECULES, 제20권 8호, pp.14022-14032
Palladium-catalyzed one-pot approach to 3-(Diarylmethylene)oxindoles from propiolamidoaryl triflate -
2015.08
| 교신저자
| HETEROCYCLES, 제91권 8호, pp.1660-1667
Synthesis of 2-(arylmethylene)-1,4-benzoxazin-3-one by one-pot sonogashira and 6-exo-dig cyclization -
2015.07
| 제1저자
| DRUG DESIGN DEVELOPMENT AND THERAPY, 제9권 0호, pp.3961-3968
Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate -
2014.02
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제24권 3호, pp.880-883
Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker -
2013.11
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제23권 21호, pp.5882-5886
2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of beta-amyloid aggregation -
2013.09
| 교신저자
| SYNLETT, 제24권 15호, pp.1993-1997
Synthesis of 3-(Diarylmethylene)oxindoles via a Palladium-Catalyzed One-Pot Reaction: Sonogashira-Heck-Suzuki-Miyaura Combined Reaction -
2013.06
| 제1저자
| NEUROCHEMISTRY INTERNATIONAL, 제62권 7호, pp.931-935
Batten disease is linked to altered expression of mitochondria-related metabolic molecules -
2013.06
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제36권 12호, pp.1904-1912
Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: Application to a pharmacokinetic study -
2013.02
| 교신저자
| EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp.965-971
Synthesis of 3,4-Dihydroisoquinolin-1-ones from N-Boc-(beta-Arylethyl)-carbamates via Isocyanate Intermediates -
2012.09
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제22권 17호, pp.5668-5674
Discovery of potent and selective rhodanine type IKK beta inhibitors by hit-to-lead strategy -
2012.08
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY, 제20권 16호, pp.4921-4935
Small molecules that protect against beta-amyloid-induced cytotoxicity by inhibiting aggregation of beta-amyloid -
2011.03
| 공동저자
| SYNTHESIS-STUTTGART, pp.867-872
A Practical and Cost-Effective Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine via a Cyclic Sulfate Intermediate -
2011.01
| 공동저자
| JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 제133권 2호, pp.214-219
Synthesis of the C ' D ' E ' F ' Domain of Maitotoxin -
2010.07
| 공동저자
| JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 제132권 28호, pp.9900-9907
Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi- and 86-epi-Diastereoisomers -
2010.04
| 제1저자
| JOURNAL OF ORGANIC CHEMISTRY, 제75권 8호, pp.2667-2680
Evolution of a Strategy for Total Synthesis of the Marine Fungal Alkaloid (+/-)-Communesin F -
2010.02
| 공동저자
| ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 제49권 11호, pp.2000-2003
Total Synthesis of the Polycyclic Fungal Metabolite (+/-)-Communesin F -
2006.12
| 공동저자
| HETEROCYCLES, 제70권, pp.143-143
An approach to cyclic alpha-amino acids by a novel hetero Diels-Alder/intramolecular hydantoin enolate alkylation strategy: An approach to halichlorine -
2006.11
| 제1저자
| JOURNAL OF ORGANIC CHEMISTRY, 제71권 23호, pp.8891-8900
Synthetic studies on perophoramidine and the communesins: Construction of the vicinal quaternary stereocenters -
2002.05
| 공동저자
| ANALYST, 제127권 7호, pp.917-920
Determination of tizanidine in human plasma by gas chromatography-mass spectrometry -
2001.05
| 공동저자
| JOURNAL OF ANTIBIOTICS, 제54권 5호, pp.460-462
New cephalosporin antibiotics with 3-triazolypyridiniummethyl substituents -
2000.06
| 공동저자
| , 제10권 11호, pp.1211-1214
Synthesis and structure - Activity relationships of quarternary ammonium cephalosporins with 3-pyrazolylpyridium derivatives -
2000.03
| 공동저자
| HETEROCYCLES, 제53권 3호, pp.529-533
1,3-Dihydro-1,3-diacetyl-2H-benzimidazol-2-one: A new versatile and selective acetylating agent -
1999.12
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제22권 6호, pp.579-584
Synthesis and in vitro antibacterial activity of quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety -
1999.08
| 공동저자
| , 제22권 4호, pp.391-397
Synthesis and in vitro antibacterial activity of C-3′ pyridinium cephalosporin derivatives
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2013.02
| 공동
| 청문각
실험의약품합성학 -
2011.03
| 공동
| 동명사
의약품합성학
-
2018.01.24
| 주발명자
| 가톨릭대학교 산학협력단
신규한 실로스타졸 염 화합물 및 이의 용도(Novel cilostazol salt compound and use thereof)
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2022.08.01
| 주발명자
| ㈜아이랩
“IL-6 생리활성을 억제하는 저분자화합물 발굴을 위한 탐색적 연구” 의 기술·노하우 이전