교수소개
세포의 환경스트레스 대응시스템에 대한 기초연구를 통해 암을 포함하는 다양한 질환의 병리를 이해하고 그 제어 방안 개발을 연구함. 서울대학교 약학대학 학사학위 수여 후 동 대학원 약학과에서 약물학 전공 박사학위를 취득하였음. 미국 Johns Hopkins 대학에서 박사후연구원-Research Scientist로 연구 활동 후 2004년부터 영남대학교 약학대학에서 부교수, 2011년부터 가톨릭대학교 약학대학에서 교수로 재직하며 분자약물학 연구실을 운영함. 다수의 국가연구개발 과제를 수행하며 주저자 SCI(E)논문 80편 이상을 발표하였으며, 다수의 학회 단체에서 위원장과 위원직을 수행하고 한국연구재단 의약학단 전문위원, 국가신약개발사업단 전문위원 등 활발한 대외활동을 수행한 바 있음.
최종학력
1997.08.21 | 서울대학교 대학원 | 약학과 | 약학박사
연구실적
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2024.05
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제47권 5호, pp.465-480
Continuous TNF‑α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation -
2024.03
| 교신저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제56권 3호, pp.501-514
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer -
2023.04
| 교신저자
| REDOX BIOLOGY, 제60권
Association of NRF2 with HIF-2?-induced cancer stem cell phenotypes in chronic hypoxic condition -
2023.03
| 교신저자
| MOLECULES AND CELLS, 제46권 3호, pp.153-164
Emerging Role of NRF2 Signaling in Cancer Stem Cell Phenotype -
2023.01
| 교신저자
| DRUG TARGETS AND THERAPEUTICS, 제2권 2호, pp.111-123
Toward a Better Understanding of NRF2/NFE2L2 and BCRP/ABCG2 in Therapy Resistance in Cancer -
2022.07
| 교신저자
| BIOMOLECULES & THERAPEUTICS, 제30권 4호, pp.368-379
High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells -
2022.01
| 교신저자
| FRONTIERS IN ONCOLOGY, 제11권
Role of CD133/NRF2 Axis in the Development of Colon Cancer Stem Cell-Like Properties -
2021.03
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제44권 3호, pp.263-280
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance -
2021.02
| 교신저자
| BIOCHEMICAL PHARMACOLOGY, 제184권
Negative correlation of urinary miR-199a-3p level with ameliorating effects of sarpogrelate and cilostazol in hypertensive diabetic nephropathy -
2020.12
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제43권 12호, pp.1297-1310
NRF2 level is negatively correlated with TGF-beta 1-induced lung cancer motility and migration via NOX4-ROS signaling -
2019.07
| 교신저자
| FREE RADICAL BIOLOGY AND MEDICINE, 제138권, pp.33-42
Bardoxolone ameliorates TGF-beta 1-associated renal fibrosis through Nrf2/Smad7 elevation -
2019.06
| 교신저자
| REDOX BIOLOGY, 제24권
Impairment of HIF-1 alpha-mediated metabolic adaption by NRF2-silencing in breast cancer cells -
2018.11
| 교신저자
| TOXICOLOGY AND APPLIED PHARMACOLOGY, 제359권, pp.24-33
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria -
2018.09
| 교신저자
| BIOMOLECULES & THERAPEUTICS, 제26권 5호, pp.487-493
Overexpression of CD44 Standard Isoform Upregulates HIF-1α Signaling in Hypoxic Breast Cancer Cells -
2018.09
| 교신저자
| CELL DEATH & DISEASE, 제9권 9호
High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling -
2018.07
| 교신저자
| REDOX BIOLOGY, 제17권, pp.246-258
High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance -
2017.11
| 교신저자
| ONCOTARGET, 제8권 63호, pp.107188-107205
NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells -
2017.11
| 교신저자
| ANTIOXIDANTS & REDOX SIGNALING, 제27권 13호, pp.945-961
NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation -
2017.03
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제40권 3호, pp.391-402
Amelioration of high fat diet-induced nephropathy by cilostazol and rosuvastatin -
2017.03
| 공동저자
| MOLECULAR PHARMACEUTICS, 제14권 3호, pp.842-855
Tempo-spatial Activation of Sequential Quadruple Stimuli for High Gene Expression of Polymeric Gene Nanocomplexes -
2016.12
| 교신저자
| CURRENT OPINION IN TOXICOLOGY, 제1권, pp.20-28
Shadows of NRF2 in cancer: Resistance to chemotherapy -
2016.09
| 교신저자
| BIOMOLECULES & THERAPEUTICS, 제24권 5호, pp.482-488
Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres -
2016.04
| 교신저자
| PLOS ONE, 제11권 4호
Beneficial effects of sarpogrelate and rosuvastatin in high fat diet/streptozotocin-induced nephropathy in mice -
2016.03
| 공동저자
| PLOS ONE, 제11권 3호, pp.0-0
Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice -
2016.01
| 교신저자
| OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 제2016권 0호, pp.0-0
Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance -
2015.08
| 교신저자
| TOXICOLOGY IN VITRO, 제29권 5호, pp.884-892
Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells -
2015.07
| 교신저자
| PLOS ONE, 제10권 7호
NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages -
2015.04
| 교신저자
| ONCOTARGET, 제6권, pp.8167-8184
Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells -
2015.03
| 교신저자
| MOLECULAR PHARMACOLOGY, 제87권, pp.465-476
The c-MET/PI3K Signaling Is Associated with Cancer Resistance to Doxorubicin and Photodynamic Therapy by Elevating BCRP/ABCG2 Expression -
2015.02
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제38권, pp.272-281
Involvement of Nrf2-GSH signaling in TGF beta 1-stimulated epithelial-to-mesenchymal transition changes in rat renal tubular cells -
2014.11
| 공동저자
| MOLECULAR CARCINOGENESIS, 제53권 11호, pp.926-937
PPAR delta Deficiency Disrupts Hypoxia-Mediated Tumorigenic Potential of Colon Cancer Cells -
2014.09
| 교신저자
| PLOS ONE, 제9권 9호
The Sensitivity of Cancer Cells to Pheophorbide a-Based Photodynamic Therapy Is Enhanced by NRF2 Silencing -
2014.08
| 교신저자
| MOLECULES, 제19권 8호, pp.12727-12759
Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease -
2014.04
| 교신저자
| PLOS ONE, 제9권 4호
Inhibitory Role of the KEAP1-NRF2 Pathway in TGF beta 1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling -
2014.02
| 공동저자
| BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 제14권 0호, pp.0-0
Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells -
2013.12
| 공동저자
| FREE RADICAL BIOLOGY AND MEDICINE, 제65권 0호, pp.552-562
Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: Structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation -
2013.09
| 공동저자
| OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 제0권 0호, pp.0-0
Nrf2 in host defense: Over the rainbow -
2013.05
| 교신저자
| OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 제0권 0호, pp.0-0
Enhanced 4-hydroxynonenal resistance in keap1 silenced human colon cancer cells -
2013.03
| 교신저자
| TOXICOLOGY LETTERS, 제218권 1호, pp.39-49
Identification of aldo-keto reductases as NRF2-target marker genes in human cells -
2013.02
| 제1저자
| ARCHIVES OF PHARMACAL RESEARCH, 제36권, pp.142-144
Where are we now in diabetic research? -
2012.11
| 교신저자
| TOXICOLOGY AND APPLIED PHARMACOLOGY, 제264권 3호, pp.431-438
Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells -
2012.10
| 공동저자
| BIOCHEMICAL PHARMACOLOGY, 제84권 7호, pp.974-983
Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction -
2012.06
| 교신저자
| TOXICOLOGY LETTERS, 제211권 3호, pp.334-341
Silver nanoparticles-mediated G2/M cycle arrest of renal epithelial cells is associated with NRF2-GSH signaling -
2012.05
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제35권 5호, pp.911-919
Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells -
2012.05
| 교신저자
| FREE RADICAL BIOLOGY AND MEDICINE, 제52권 9호, pp.1773-1785
NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity -
2012.01
| 교신저자
| TOXICOLOGY AND APPLIED PHARMACOLOGY, 제258권 1호, pp.89-98
Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity -
2011.12
| 교신저자
| 약학회지, 제55권 6호, pp.466-472
Nrf2 영구 넉다운 난소암 세포주의 Proteasome 저해 항암제 Bortezomib에 대한 감수성 증가
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2019.06
| 공동
| 신일서적
(이우주의) 약리학 강의 -
2015.02
| 공동
| 범문에듀케이션
약물학 -
2013.02
| 공동
| 신일북스
임상약리와 약물치료
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2018.12.27
| 주발명자
| 가톨릭대학교 산학협력단
프라바스타틴(pravastatin) 및 항혈소판제를 유효성분으로 함유하는 신장 질환 예방 또는 치료용 조성물 -
2017.03.31
| 주발명자
| 가톨릭대학교 산학협력단
ｃ－ΜΕΤ 억제제를 유효성분으로 포함하는 독소루비신 및 광역학 치료 항암 효과 증진용 약학 조성물(Pharmaceutical composition for enhancing effect to doxorubicin and Photodynamic therapy against cancer comprising c-MET inhibitor)