학과장
이기연 부교수
Lee, Kiyoun
- 02-2164-5528
- kiyoun@catholic.ac.kr
- 다솔관 D615
연구분야
유기합성
연구키워드
천연물 전합성 / 의약합성 / 유기반응개발
교수소개
유기반응 개발, 의약합성 및 천연물 전합성에 관한 연구를 하고 있다. 2012년 미국 듀크대학교 (Duke University) 화학과에서 항암제, 항생제 등 흥미로운 생리활성 기능을 가지고 있는 천연물의 전합성 연구로 박사학위를 취득하였다. 이후 미국 스크립스 (Scripps Research) 연구소에서 박사후 연구원으로 재직하였으며 2015년 9월부터 가톨릭대학교 화학과에서 유기합성 연구실을 운영해 오고 있다.
Kiyoun's research interests include organic reaction development, pharmaceutical synthesis, and the total synthesis of natural products. He received his Ph.D. in 2012 from Duke Univ. Department of Chemistry, USA, focusing on the total synthesis of natural products with interesting biological functions, such as anticancer drugs and antibiotics. He was a postdoctoral fellow at Scripps Research Institute in the USA before becoming the principal investigator of the organic synthesis laboratory at The Catholic University of Korea in September 2015.
최종학력
2012.12.31 | 듀크 (Duke) 대학교 | 화학과 | 이학박사
연구실적
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2026.07
| 교신저자
| ADVANCED SCIENCE, 제13권 41호, pp.1-25
Molecular Dynamics-Guided Sterol Engineering of mRNA-Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen-Selective Immunity -
2026.07
| 교신저자
| ADVANCED SCIENCE, 제13권 41호, pp.1-21
Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery -
2026.01
| 교신저자
| JOURNAL OF ORGANIC CHEMISTRY, 제91권 2호, pp.1209-1214
Stereoselective Synthesis of 4,5-Disubstituted Oxazolidin-2-ones via Tandem Lossen Rearrangement and Ring Closure of Asymmetric Aldol Adducts -
2025.02
| 교신저자
| SMALL, 제21권 8호
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning -
2024.09
| 교신저자
| SMALL, 제21권 8호
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning -
2024.02
| 교신저자
| MOLECULES, 제29권 3호
Divergent Syntheses of (-)-Chicanine, (+)-Fragransin A2, (+)-Galbelgin, (+)-Talaumidin, and (+)-Galbacin via One-Pot Homologative γ-Butyrolactonization -
2022.12
| 교신저자
| ORGANIC LETTERS
Nickel Carbene-Mediated One-Carbon Homologative gamma-Butyrolactonization -
2022.04
| 교신저자
| ORGANIC LETTERS, 제24권 15호, pp.2926-2930
Total Synthesis of Gymnothelignan K via a One-Pot Homologative?-Butyrolactonization -
2022.03
| 교신저자
| JOURNAL OF ORGANIC CHEMISTRY, 제87권 6호, pp.4316-4322
Divergent Total Syntheses of Gymnothelignan N, Beilschmin A, and Eupomatilones 1, 3, 4, and 7 -
2021.02
| 교신저자
| MOLECULES, 제26권 3호
Stereoselective Synthesis of Oxazolidin-2-ones via an Asymmetric Aldol/Curtius Reaction: Concise Total Synthesis of (-)-Cytoxazone -
2020.02
| 교신저자
| EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 제2020권 6호, pp.689-692
A Stereoselective Formal Synthesis of Quinolizidine (-)-217A -
2019.11
| 교신저자
| ANALYTICAL CHEMISTRY, 제91권 22호, pp.14705-14711
Discrimination between Human Colorectal Neoplasms with a Dual-Recognitive Two-Photon Probe -
2019.09
| 교신저자
| ORGANIC LETTERS, 제21권 19호, pp.7857-7862
Synthesis of gamma-Lactones via the Kowalski Homologation Reaction: Protecting-Group-Free Divergent Total Syntheses of Eupomatilones-2,5,6, and 3-epi-Eupomatilone-6 -
2019.06
| 공동저자
| ANALYTICAL CHEMISTRY, 제91권 14호, pp.9246-9250
Ratiometric Detection of gamma-Glutamyltransferase in Human Colon Cancer Tissues Using a Two-Photon Probe -
2019.06
| 공동저자
| NATURE COMMUNICATIONS, 제10권
Chemical logic of MraY inhibition by antibacterial nucleoside natural products -
2018.06
| 교신저자
| SYNLETT, 제29권 9호, pp.1203-1206
A Concise Total Synthesis of (+/-)-Mesembrine -
2018.02
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제28권 16호, pp.2746-2750
Synthetic efforts towards the stereoselective synthesis of NF00659B(1) -
2017.01
| 제1저자
| SYNLETT, 제28권 2호, pp.249-252
Total Synthesis of (±)-Decytospolides A and B -
2016.12
| 제1저자
| NATURAL PRODUCT REPORTS, 제33권 12호, pp.1393-1424
Advances in the synthesis of glycosidic macrolides: Clavosolides A-D and cyanolide A -
2015.09
| 제1저자
| TETRAHEDRON, 제71권 35호, pp.5897-5905
Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs -
2015.06
| 제1저자
| TETRAHEDRON, 제71권 22호, pp.3741-3746
Total synthesis of (-)-kopsinine and ent-(+)-kopsinine -
2014.10
| 공동저자
| SYNLETT, 제25권, pp.2794-2796
Total Synthesis of Acetylcholinesterase Inhibitor Macakurzin C -
2014.10
| 공동저자
| RSC ADVANCES, 제4권 95호, pp.52637-52639
Concise and stereoselective synthesis of (±)-Hagen's gland lactone -
2014.07
| 공동저자
| ELIFE, 제3권 July2014호, pp.1-19
Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters -
2014.02
| 제1저자
| JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 제136권 8호, pp.3312-3317
Total Syntheses of (-)-Kopsifoline D and (-)-Deoxoapodine: Divergent Total Synthesis via Late-Stage Key Strategic Bond Formation -
2012.08
| 공동저자
| ACS CHEMICAL BIOLOGY, 제7권 11호, pp.1873-1883
Manipulating JNK signaling with (-)-zuonin A -
2012.06
| 제1저자
| ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 제51권 23호, pp.5735-5738
N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide -
2012.02
| 제1저자
| EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 5호, pp.1025-1032
Stereoselective Synthesis of Tetrahydropyrans through Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A -
2011.05
| 제1저자
| ORGANIC LETTERS, 제13권 10호, pp.2722-2725
A Stereoselective Formal Synthesis of Leucascandrolide A -
2009.11
| 제1저자
| ORGANIC LETTERS, 제11권 22호, pp.5202-5205
A Facile and Efficient Synthesis of 4-Hydroxy-2,6-cis-tetrahydropyrans via Tandem Cross-Metathesis/Thermal S(N)2 ' Reaction: Protecting-Group-Free Synthesis of (+/-)-Diospongin A -
2008.09
| 제1저자
| SYNTHETIC COMMUNICATIONS, 제38권, pp.3251-3259
New cyclization route to the skeletons of lennoxamine and chilenine -
2006.03
| 공동저자
| JOURNAL OF ORGANIC CHEMISTRY, 제71권, pp.2185-2187
New palladium-catalyzed reaction pathway to the Erythrina skeleton
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2014.05
| 단독
| Springer
Stereoselective syntheses of tetrahydropyrans : applications to the synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A
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2026.03.30
| 공동발명자
| 가톨릭대학교 산학협력단
방향족 모이어티를 가지는 지질 화합물 및 이를 포함하는 지질 나노 입자 조성물(LIPID COMPOUND HAVING AROMATIC MOIETY AND LIPID NANO PARTICL COMPOSITION INCLUDING THEREOF) -
2023.11.28
| 주발명자
| 가톨릭대학교 산학협력단
옥사졸리딘-2-온 유도체 및 이의 제조 방법
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2024.11.01
| 공동발명자
| (주)에스엠엘바이오팜
'발현 벡터 포함 약학 조성물 및 지질 나노 입자 조성물'의 기술이전(양도)