교수소개
(김 필 교수의 전문성 관련 기사) -먹으면 살 빠지는 대체육 나올까 (https://health.chosun.com/site/data/html_dir/2024/06/20/2024062002211.html) -미생물이 만든 대체단백질, 우주식량으로도 쓰인다 (https://www.dongascience.com/news.php?idx=66206) -2024 대한민국 과학축제 전시 (https://blog.naver.com/cabiotech/223461357900) -식물성 대체육은 진화 중 (https://m.health.chosun.com/svc/news_view.html?contid=2022081902155) -옛날 '콩고기'는 잊어라 (https://m.health.chosun.com/svc/news_view.html?contid=2022090601883) -그린바이오산업 소개 대중강연 및 인터뷰 (https://youtu.be/HcGqMOFbVGg?si=okJ61E98FdplyIjS; https://youtu.be/S765usMmo6w?si=ogQaq9bbQuRN) -대체단백질식품신소재 원천기술연구단 소식 (https://blog.naver.com/cabiotech)
Professor Pil KIM graduated his bachelor’s degree at Korea University (Food Technology), master and Ph. D. degrees at KAIST (Biological Sciences). He has conducted postdoc fellows at KRIBB (Fermentation Systems RU) and at Michigan State University (Dept. of Biochemistry and Molecular Biology) as well as at the Tongyang Confectionery Co. as a special military service before the assignment as a full-time professor at the Catholic Univ. of Korea (Dept. of Biotechnology) since 2004. He has been studying on developments of biologics/biotics based on metabolic engineering and cellular evolutionary engineering of single-cells and proteins, on microbial energy metabolism and its physiology. He has accomplished Technology Fee Incomes and has founded a company during his adjunct professorshi. He is a current director of a research group composing 10 domestic institutes entitled “Development of Novel Food Ingredients for Alternative Proteins” funded by Korean Ministry of Science, Technology, and ICT.
최종학력
1998.02.25 | 한국과학기술원 | 생명과학과 | 이학박사
연구실적
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2024.09
| 교신저자
| FOOD BIOSCIENCE, 제62권 0호, pp.105062-105062
Dietary heme-enriched Corynebacterium extract exerts health benefits by reshaping gut microbiota -
2024.05
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제25권 11호, pp.5824-5824
Development of a Normal Porcine Cell Line Growing in a Heme-Supplemented, Serum-Free Condition for Cultured Meat -
2024.04
| 교신저자
| BIOPROCESS AND BIOSYSTEMS ENGINEERING, 제47권 4호, pp.549-556
Development strategy of non-GMO organism for increased hemoproteins in Corynebacterium glutamicum: a growth-acceleration-targeted evolution -
2024.02
| 교신저자
| FOOD SCIENCE & NUTRITION TECHNOLOGY, 제9권 1호, pp.1-13
Safety Regulations of Edible Ingredients Derived from Corynebacterium glutamicum -
2023.12
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제33권 12호, pp.1648-1656
Single-Cell Hemoprotein Diet Changes Adipose Tissue Distributions and Re-Shapes Gut Microbiota in High-Fat Diet-Induced Obese Mice -
2023.03
| 교신저자
| FOOD SCIENCE AND BIOTECHNOLOGY, 제32권 4호, pp.489-496
Single-cell hemoprotein (heme-SCP) exerts the prebiotic potential to establish a healthy gut microbiota in small pet dogs -
2022.11
| 공동저자
| MICROBIOLOGY SPECTRUM
Transcriptional Potential Determines the Adaptability of Escherichia coli Strains with Different Fitness Backgrounds -
2021.03
| 교신저자
| MICROBIOLOGY AND BIOTECHNOLOGY LETTERS, 제49권 1호, pp.57-64
Effect of heme-rich nutrient on anaerobic bacterial growth and survival: A model study on lactobacillus Gasseri -
2020.12
| 교신저자
| FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 제8권
Reverse Engineering Targets for Recombinant Protein Production in Corynebacterium glutamicum Inspired by a Fast-Growing Evolved Descendant -
2020.09
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제30권 9호, pp.1420-1429
Accelerated Growth of Corynebacterium glutamicum by Up-Regulating Stress-Responsive Genes Based on Transcriptome Analysis of a Fast-Doubling Evolved Strain -
2020.06
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제30권 6호, pp.793-803
Current Status and Applications of Adaptive Laboratory Evolution in Industrial Microorganisms -
2019.09
| 교신저자
| MICROBIOLOGY AND BIOTECHNOLOGY LETTERS, 제47권 3호, pp.337-342
Effect of promoters on the heme production in a recombinant corynebacterium glutamicum -
2018.09
| 교신저자
| FRONTIERS IN MICROBIOLOGY, 제9권
Recombinant Protein Expression System in Corynebacterium glutamicum and Its Application -
2018.07
| 교신저자
| BIOTECHNOLOGY JOURNAL, 제13권 7호
Genome Variations of Evolved Escherichia coli ET8 With a Rhodopsin-Based Phototrophic Metabolism -
2018.05
| 공동저자
| ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 제111권 5호, pp.641-648
Corynebacterium glutamicum WhcD interacts with WhiA to exert a regulatory effect on cell division genes -
2017.03
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제27권 3호, pp.500-506
Heme derived from Corynebacterium glutamicum: A potential iron additive for swine and an electron carrier additive for lactic acid bacterial culture -
2017.03
| 교신저자
| MICROBIAL CELL FACTORIES, 제16권
An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli -
2016.11
| 공동저자
| JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 제43권 11호, pp.1625-1630
Carboxyl-terminal domain characterization of polyene-specific P450 hydroxylase in Pseudonocardia autotrophica -
2016.09
| 교신저자
| JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 제2016권 115호
Procedure for adaptive laboratory evolution of microorganisms using a chemostat -
2016.08
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제26권 8호, pp.1452-1456
A strategy to increase microbial hydrogen production, facilitating intracellular energy reserves -
2016.05
| 공동저자
| APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 제100권 9호, pp.4063-4072
SpiE interacts with Corynebacterium glutamicum WhcE and is involved in heat and oxidative stress responses -
2016.05
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제26권 5호, pp.807-822
The actinobacterium Corynebacterium glutamicum, an industrial workhorse -
2016.01
| 공동저자
| RESEARCH IN MICROBIOLOGY, 제167권 1호, pp.20-28
Involvement of the osrR gene in the hydrogen peroxide-mediated stress response of Corynebacterium glutamicum -
2015.08
| 공동저자
| PROCESS BIOCHEMISTRY, 제50권 8호, pp.1184-1193
Genome mining of rare actinomycetes and cryptic pathway awakening -
2015.06
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제25권 6호, pp.880-886
Analysis of Heme Biosynthetic Pathways in a Recombinant Escherichia coli -
2015.03
| 교신저자
| JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 제42권 6호, pp.915-924
Growth retardation of Escherichia coli by artificial increase of intracellular ATP -
2014.11
| 공동저자
| JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 제65권 10호, pp.1551-1554
Soft X-ray synchrotron radiation spectroscopy study of molecule-based nanoparticles -
2014.04
| 교신저자
| AMB EXPRESS, 제4권 1호, pp.1-7
Artificial oxidative stress-tolerant corynebacterium glutamicum -
2013.10
| 공동저자
| JOURNAL OF BIOTECHNOLOGY, 제168권 2호, pp.149-154
Regulatory interaction of the Corynebacterium glutamicum whc genes in oxidative stress responses -
2013.09
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제23권 10호, pp.1365-1371
A wblA-binding protein, spiA, involved in streptomyces oxidative stress response -
2013.07
| 공동저자
| APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 제79권 13호, pp.4159-4163
Repression of Antibiotic Downregulator WblA by AdpA in Streptomyces coelicolor -
2013.06
| 교신저자
| ENZYME AND MICROBIAL TECHNOLOGY, 제53권 1호, pp.13-17
Estimation of phosphoenolpyruvate carboxylation mediated by phosphoenolpyruvate carboxykinase (PCK) in engineered Escherichia coli having high ATP -
2013.05
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제23권 5호, pp.668-673
Effect of gene amplifications in porphyrin pathway on heme biosynthesis in a recombinant Escherichia coli -
2013.04
| 교신저자
| BIOTECHNOLOGY LETTERS, 제0권 0호, pp.1-9
Adaptive evolution of Corynebacterium glutamicum resistant to oxidative stress and its global gene expression profiling -
2012.12
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제22권 12호, pp.1653-1658
Porphyrin derivatives from a recombinant Escherichia coli grown on chemically defined medium -
2012.06
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제22권 6호, pp.736-741
Negative role of wblA in response to oxidative stress in Streptomyces coelicolor -
2012.06
| 공동저자
| FEMS MICROBIOLOGY LETTERS, 제331권 1호, pp.63-69
The role of Corynebacterium glutamicum spiA gene in whcA-mediated oxidative stress gene regulation -
2012.04
| 교신저자
| JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 제0권 0호, pp.0-0
Activity improvement of UDP-galactose-4-epimerase for tagatose substrates by 3D structure-based combinatorial mutagenesis -
2012.01
| 공동저자
| JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 제0권 0호, pp.1-7
Minimal polyketide pathway expression in an actinorhodin cluster-deleted and regulation-stimulated Streptomyces coelicolor -
2011.12
| 교신저자
| APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 제0권 0호, pp.1-8
An engineered Escherichia coli having a high intracellular level of ATP and enhanced recombinant protein production -
2011.07
| 공동저자
| NATURE CHEMICAL BIOLOGY, 제7권 7호, pp.434-436
FrsA functions as a cofactor-independent decarboxylase to control metabolic flux -
2011.05
| 교신저자
| LETTERS IN APPLIED MICROBIOLOGY, pp.0-0
Alteration of reducing powers in an isogenic phosphoglucose isomerase (pgi)-disrupted Escherichia coli expressing NAD(P)-dependent malic enzymes and NADP-dependent glyceraldehyde 3-phosphate dehydrogenase -
2011.09
| 공동저자
| FEMS MICROBIOLOGY LETTERS, 제322권 1호, pp.8-14
Identification of SpiA that interacts with Corynebacterium glutamicum WhcA using a two-hybrid system -
2011.04
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제21권 4호, pp.374-378
Metagenome Resource for D-Serine Utilization in a DsdA-Disrupted Escherichia coli -
2011.02
| 교신저자
| APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 제163권 3호, pp.444-451
Novel Activity of UDP-Galactose-4-Epimerase for Free Monosaccharide and Activity Improvement by Active Site-Saturation Mutagenesis -
2011.01
| 교신저자
| JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 제111권 1호, pp.26-30
Long-term continuous adaptation of Escherichia coli to high succinate stress and transcriptome analysis of the tolerant strain -
2010.06
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제20권, pp.1018-1021
Escherichia coli Arabinose Isomerase and Staphylococcus aureus Tagatose-6-Phosphate Isomerase: Which is a Better Template for Directed Evolution of Non-Natural Substrate Isomerization? -
2009.03.31
| 교신저자
| FOOD BIOTECHNOLOGY, 제23권, pp.8-16
Characterization of L-Arabinose Isomerase in Bacillus subtilis, a GRAS Host, for the Production of Edible Tagatose -
2009.09
| 공동저자
| BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 제14권, pp.551-558
Overexpression, Purification, and Functional Characterization of the Group II Chaperonin from the Hyperthermophilic Archaeum Pyrococcus horikoshii OT3 -
2009.06
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제19권, pp.604-609
Potential Application of the Recombinant Escherichia coli-Synthesized Heme as a Bioavailable Iron Source -
2009.02
| 교신저자
| CURRENT MICROBIOLOGY, 제58권, pp.159-163
Comparison of the Effects of NADH- and NADPH-Perturbation Stresses on the Growth of Escherichia coli -
2009.01
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제19권, pp.51-54
LC-MS/MS Profiling-Based Secondary Metabolite Screening of Myxococcus xanthus -
2008.08
| 공동저자
| BIOLOGICAL & PHARMACEUTICAL BULLETIN, 제31권, pp.1559-1564
Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats -
2008.06
| 교신저자
| FOOD SCIENCE AND BIOTECHNOLOGY, 제17권, pp.655-658
Comparative analysis of tagatose productivity of immobilized l-arabinose isomerase expressed in Escherichia coli and Bacillus subtilis -
2008.04
| 교신저자
| BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 제72권, pp.1138-1141
A physiology study of Escherichia coli overexpressing phosphoenolpyruvate carboxykinase -
2007.12
| 교신저자
| JOURNAL OF APPLIED MICROBIOLOGY, 제103권, pp.2340-2345
The effect of NADP-dependent malic enzyme expression and anaerobic C4 metabolism in Escherichia coli compared with other anaplerotic enzymes -
2007.09
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제17권 9호, pp.1579-1584
5-aminolevulinic acid biosynthesis in Escherichia coli coexpressing NADP-dependent malic enzyme and 5-aminolevulinate synthase -
2007.08
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제17권 8호, pp.1353-1360
Expression analysis of the csp-like genes from Corynebacterium glutamicum encoding homologs of the Escherichia coli major cold-shock protein CspA -
2007.06
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제17권, pp.1010-1017
Biochemical analysis on the parallel pathways of methionine biosynthesis in Corynebacterium glutamicum -
2006.12
| 교신저자
| JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 제43권, pp.108-112
Modification of optimal pH in L-arabinose isomerase from Geobacillus stearothermophilus for D-galactose isomerization -
2006.09
| 교신저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제16권, pp.1448-1452
Influence of gluconeogenic phosphoenolpyruvate carboxykinase (PCK) expression on succinic acid fermentation in Escherichia coli under high bicarbonate condition -
2006.03
| 교신저자
| 한국미생물.생명공학회지, 제34권 1호, pp.35-39
반추위 미생물이 가진 Phosphoenolpyruvate에서 Oxaloacetate 경로 조절기작의 대장균에서의 모사와 C4대사의 영향 -
2006.03
| 공동저자
| BIOTECHNOLOGY LETTERS, 제28권, pp.357-362
Cloning and production of a novel bacteriocin, lactococcin K, from Lactococcus lactis subsp lactis MY23 -
2005.12.01
| 공동저자
| BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 제10권, pp.494-499
Characterization a novel lipopolysaccharide biosurfactant from Klebsiella oxitoca -
2005.11.01
| 공동저자
| BIOCHEMICAL AND BIOPHYSICAL RESERCH COMMUNICATIONS, 제337권, pp.757-764
The whcE ofCorynebacterium glutamicumis important for survival following heat and oxidative stress -
2005.06.01
| 공동저자
| BIOCHEMICAL AND BIOPHYSICAL RESERCH COMMUNICATIONS, 제331권, pp.1542-1547
Functional analysis of sigH expression in Corynebacterium glutamicum -
2005.06.01
| 교신저자
| 한국미생물.생명공학회지, 제33권 2호, pp.106-111
Staphylococcus aureus유래의 비금속 이성화효소인tagatose-6-phosphate isomerase의 기질다양성 -
2004.12.01
| 공동저자
| BIOTECHNOLOGY PROGRESS, 제20권, pp.1876-1879
Lactosucrose bioconversion from lactose and sucrose by whole cells of Paenibacillus polymixa harboring levansucrase activity -
2004.08.01
| 교신저자
| APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 제65권 3호, pp.243-249
Current studies on biological tagatose production using L-arabinose isomerase: A review and future perspective -
2004.05.01
| 공동저자
| BIOTECHNOLOGY LETTERS, 제26권, pp.623-627
Increased xylitol production rate during long-term cell recycle fermentation of Candida tropicalis -
2004.03.01
| 공동저자
| APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 제70권 2호, pp.1238-1241
Effect of overexpression of Actinobacillus succinogenes phosphoenolpyruvate carboxykinase on succinate production in Escherichia coli -
2004.02.01
| 공동저자
| PLASMID, 제51권, pp.108-115
Construction of a shuttle vector for the overexpression of recombinant proteins in Actinobacillus succinogenes
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2017.01.03
| 주발명자
| 가톨릭대학교 산학협력단
분자 진화에 의해 수득된 안전성 균주 유래 효소 및 그를 포함하는 안전성 코리네박테리움 글루타미쿰(GRAS strain-derived enzyme obtained by molecular evlution and GRAS Corynebaterium glutamicum having the same) -
2016.02.01
| 주발명자
| 가톨릭대학교 산학협력단
항산화 활성이 우수한 코리네박테리움 글루타미쿰 및 이의 용도(Corynebacterium glutamicum having antioxidant activity and use thereof) -
2015.11.23
| 주발명자
| 가톨릭대학교 산학협력단
재조합 코리네박테리움 글루타미쿰 및 그의 용도(Recombinant Corynebacterium glutamicum and use thereof) -
2015.04.01
| 주발명자
| 가톨릭대학교 산학협력단
헴 생산성이 증가된 재조합 대장균 및 이를 이용한 헴 생산 방법(Recombinant microorganism having enhanced heme productivity and biological method of producing heme using the same) -
2014.07.31
| 주발명자
| 주식회사 인트론바이오테크놀로지,가톨릭대학교 산학협력단
생물학적 헴철 생산 방법 및 그에 의해 생산된 헴철 추출물을 포함하는 철분보충 조성물(METHOD FOR PRODUCING BIOLOGICAL HEME IRON, AND IRON SUPPLEMENTING COMPOSITION CONTAINING THE HEME IRON PRODUCED BY SAME) -
2012.02.01
| 주발명자
| 가톨릭대학교 산학협력단
세포내 에너지 농도가 높은 세포 및 그의 용도(High energy charged cell and use thereof)
-
2021.04.01
| 주발명자
| (주)헤모랩
(주)헤모랩 교원창업기업 기술료 납부 -
2020.05.08
| 주발명자
| (주)헤모랩
(주)헤모랩 교원창업기업 결산에 따른 기술료 -
2017.12.01
| 주발명자
| (주)만방바이오
“막단백질 발현용 비-유전자 재조합 대장균 균주 및 그를 이용한 막단백질 생산 방법” 기술의 실시계약 -
2011.04.25
| 주발명자
| (주)인트론테크노바이올로지
생물학적 헴철 생산 방법 및 그에 의해 생산된 헴철 추출물을 포함하는 철분보충 조성물 -
2010.01.21
| 주발명자
| (주)화인
생물학적 헴철 생산 방법 및 그에 의해 생산된 헴철 추출물을 포함하는 철분보충 조성물