이혜숙 교수
Lee Hyesuk
- 02-2164-4061
- sianalee@catholic.ac.kr
- 정진석추기경약학관 NP421
연구분야
약물대사 및 생의약분석
연구키워드
약물대사
법독성학
약물상호작용
교수소개
약독물의 약동학 및 대사경로 구명, 약물 뿐아니라 사회문제가 되는 신종마약류의 다양한 bioanalysis 분석법 및 약물상호작용 연구와 지질대사체학 및 단백질체학 등의 통합적 오믹스 연구시스템의 연구기반을 구축하여 대사체학과 단백질체학을 이용한 질병 관련한 생체지표 개발 연구를 수행해 오고 있으며, SCI 국제학술지에 250여편의 논문을 발표하였다. 2008년-2013년에 국가지정연구실사업(과제명: 천연물신약의 대사 및 약물상호작용 평가 기술 연구)으로 약동력학, 대사 및 약물상호작용 연구기반과 을 확보하여, 국내 제약회사의 신약개발 연구를 지원하여 현재 시판 중이거나 임상시험 중인 9건의 혁신신약 (자이데나, 슈가논, 엠빅스, 엔블로 등)과 천연물신약 (스티렌, 모틸리톤, 시네츄라시럽 등) 개발에 기여하였다. 국제저명학술지인 Current Analytical Chemistry, Integrative Medicine Research, Pharmaceutics의 편집위원으로 활동 중이며, 과기정통부 장관 표창(2016, 2021), 대한약학회 녹암학술상(2017), 가톨릭대 연구우수상(2016), 가톨릭대 최우수 강의교원(2014) 등을 수상하였다.
Professor Lee acquired B.S., MS, Ph.D. degrees at the College of Pharmacy, Sungkyunkwan University, Korea. I have worked as a senior researcher in Toxicology Research Center, Korea Research Institute of Chemical Technology. I also served as professor in College of Pharmacy, Wonkwang University, Korea from 1995 to 2010 and was a dean of College of Pharmacy, Wonkwang University from 2003 to 2005. In 2011, I moved to College of Pharmacy, The Catholic University of Korea and was a dean of College of Pharmacy from 2014 to 2016. I have published 250 peer-reviewed articles in SCIE journals, and my research has focused on analytical toxicology, pharmacokinetics and metabolism of new drug candidates and new psychoactive substances, and in vitro drug interaction. I serve on the Editorial board members of Pharmaceutics, Bioanalysis, Current Analytical Chemistry, Integrative Medicine Research, and Mass Spectrometry Letters.
최종학력
1989.08.31 | 성균관대학교 | 약학과 | 박사
연구실적
-
2024.09
| 공동저자
| ADVANCED DRUG DELIVERY REVIEWS, 제212권
Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond -
2024.07
| 공동저자
| MACROMOLECULAR BIOSCIENCE, 제24권 7호
Beyond Nanoparticle-Based Intracellular Drug Delivery: Cytosol/Organelle-Targeted Drug Release and Therapeutic Synergism -
2024.06
| 공동저자
| BIOMATERIALS SCIENCE, 제12권 12호, pp.3045-3067
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting -
2024.06
| 교신저자
| PHARMACEUTICS, 제16권 6호
In Vitro Metabolism and Transport Characteristics of Zastaprazan -
2024.04
| 공동저자
| CELL DEATH & DISEASE, 제15권 4호
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance -
2024.04
| 공동저자
| SCIENTIFIC REPORTS, 제14권 1호
Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis -
2024.03
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제56권 3호, pp.686-699
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death -
2024.02
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제47권 2호, pp.111-126
Comparative metabolism of aschantin in human and animal hepatocytes -
2024.01
| 교신저자
| TOXICOLOGICAL RESEARCH, 제40권 1호, pp.125-137
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes -
2023.12
| 교신저자
| CHEMICO-BIOLOGICAL INTERACTIONS, 제386권
Identification of α-amanitin effector proteins in hepatocytes by limited proteolysis-coupled mass spectrometry -
2023.09
| 교신저자
| FOOD AND CHEMICAL TOXICOLOGY, 제179권
Toxicokinetics and tissue distribution of phalloidin in mice -
2023.06
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제46권 6호, pp.500-534
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases -
2023.06
| 공동저자
| BIOMEDICINE & PHARMACOTHERAPY, 제162권
Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression -
2023.04
| 교신저자
| TOXICOLOGICAL RESEARCH, 제39권 2호, pp.251-262
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling -
2023.01
| 공동저자
| CHEMICAL ENGINEERING JOURNAL, 제456권
e-Poly(L-lysine)-based bioreducible nanogels for mitochondria-targeted delivery and release: Hydrophobicity-tuned nucleus-to-mitochondria organelle-targeting switch and slow disulfide cleavage -
2023.01
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제46권 1호, pp.44-58
MEKs/ERKs-mediated FBXO1/E2Fs interaction interference modulates G(1)/S cell cycle transition and cancer cell proliferation -
2022.12
| 교신저자
| MASS SPECTROMETRY LETTERS, 제13권 4호, pp.95-105
Mass Spectrometry-Based Analytical Methods of Amatoxins in Biological Fluids to Monitor Amatoxin-Induced Mushroom Poisoning -
2022.12
| 공동저자
| CHEMOSPHERE, 제309권
Simple and rapid method for 336 multiresidual pesticide analysis in saliva, determination of their chemical stabilities, and biomonitoring of farmers -
2022.10
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제23권 20호
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells -
2022.10
| 공동저자
| FRONTIERS IN MOLECULAR BIOSCIENCES, 제9권
Inflammasomes and their roles in arthritic disease pathogenesis -
2022.09
| 공동저자
| BIOMOLECULES & THERAPEUTICS
Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation -
2022.04
| 교신저자
| PHARMACEUTICS, 제14권 4호
Toxicokinetics of β-Amanitin in Mice and In Vitro Drug–Drug Interaction Potential -
2022.04
| 교신저자
| FRONTIERS IN PHARMACOLOGY, 제13권 0호, pp.853971-853971
Urinary Profile of Endogenous Gamma-Hydroxybutyric Acid and its Biomarker Metabolites in Healthy Korean Females: Determination of Age-Dependent and Intra-Individual Variability and Identification of Metabolites Correlated With Gamma-Hydroxybutyric Acid -
2022.03
| 교신저자
| MASS SPECTROMETRY LETTERS, 제13권 1호, pp.20-25
Quantification of Fargesin in Mouse Plasma Using Liquid Chromatography-High Resolution Mass Spectrometry: Application to Pharmacokinetics of Fargesin in Mice -
2022.02
| 교신저자
| ANALYTICA CHIMICA ACTA, 제1194권
Derivatization-assisted LC-MS/MS method for simultaneous quantification of endogenous gamma-hydroxybutyric acid and its metabolic precursors and products in human urine -
2022.01
| 교신저자
| BIOMATERIALS, 제280권
Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability -
2022.01
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제54권 1호, pp.35-46
FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells -
2021.12
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells -
2021.11
| 공동저자
| PHARMACEUTICALS, 제14권 11호
Rig-i deficiency promotes obesity-induced insulin resistance -
2021.11
| 공동저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 제84권 22호, pp.922-931
Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells -
2021.10
| 교신저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 제84권 20호, pp.821-835
Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug–drug interaction potentials -
2021.09
| 교신저자
| MASS SPECTROMETRY LETTERS, 제12권 3호, pp.112-117
Simultaneous determination of α-amanitin and β-amanitin in mouse plasma using liquid chromatography-high resolution mass spectrometry -
2021.09
| 공동저자
| 대한암예방학회지, 제26권 3호, pp.174-182
F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2 -
2021.08
| 공동저자
| CHEMOSPHERE, 제277권
Method for the simultaneous analysis of 300 pesticide residues in hair by LC-MS/MS and GC-MS/MS, and its application to biomonitoring of agricultural workers -
2021.03
| 교신저자
| TOXINS, 제13권 3호
Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro -
2021.03
| 공동저자
| CELLS, 제10권 3호
Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy -
2021.02
| 공동저자
| ADVANCED FUNCTIONAL MATERIALS, 제31권 6호
Disrupting the Redox Balance with a Diselenide Drug Delivery System: Synergistic or Antagonistic? -
2021.02
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제22권 4호, pp.1-18
Fargesin inhibits egf-induced cell transformation and colon cancer cell growth by suppression of CDK2/cyclin E signaling pathway -
2021.02
| 교신저자
| PHARMACEUTICS, 제13권 2호
Tetrahydrofurofuranoid lignans, eudesmin, fargesin, epimagnolin a, magnolin, and yangambin inhibit UDP-glucuronosyltransferase 1A1 and 1A3 activities in human liver microsomes -
2021.02
| 공동저자
| FRONTIERS IN IMMUNOLOGY, 제11권
Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules -
2021.02
| 공동저자
| MOLECULES, 제26권 4호
Loganin alleviates gout in ammation by suppressing NLRP3 in ammasome activation and mitochondrial damage -
2021.02
| 교신저자
| XENOBIOTICA, 제51권 2호, pp.194-201
Pharmacokinetic interaction between dronedarone and ticagrelor following oral administration in rats -
2021.01
| 공동저자
| PHARMACEUTICS, 제13권 1호, pp.1-17
Involvement of organic anion transporters in the pharmacokinetics and drug interaction of rosmarinic acid -
2021.01
| 공동저자
| ARCHIVES OF PHARMACAL RESEARCH, 제44권 1호, pp.16-35
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases -
2021.01
| 공동저자
| CLINICAL AND TRANSLATIONAL SCIENCE, 제14권 1호, pp.231-238
An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans -
2020.11
| 교신저자
| PHARMACEUTICS, 제12권 11호, pp.1-18
Inhibitory effect of AB-PINACA, indazole carboxamide synthetic cannabinoid, on human major drug-metabolizing enzymes and transporters -
2020.10
| 교신저자
| MOLECULES, 제25권 19호
In vitro interaction of AB-FUBINACA with human cytochrome P450, UDP-Glucuronosyltransferase enzymes and drug transporters -
2020.09
| 교신저자
| MASS SPECTROMETRY LETTERS, 제11권 3호, pp.59-64
Determination of mertansine in rat plasma using liquid chromatography-tandem mass spectrometry and pharmacokinetics of mertansine in rats -
2020.09
| 공동저자
| EXPERIMENTAL AND MOLECULAR MEDICINE, 제52권 9호, pp.1526-1536
Stat2 stability regulation: an intersection between immunity and carcinogenesis -
2020.09
| 교신저자
| PHARMACEUTICS, 제12권 9호, pp.1-17
In vitro metabolism of DWP16001, a novel sodium-glucose cotransporter 2 inhibitor, in human and animal hepatocytes -
2020.09
| 공동저자
| BIOMOLECULES & THERAPEUTICS, 제28권 5호, pp.437-442
Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome -
2020.08
| 공동저자
| BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 제1866권 8호
Mitochondria-targeted drug delivery in cancers -
2020.07
| 교신저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1149권
Liquid chromatography-high resolution mass spectrometry for the determination of three cannabinoids, two (−)-trans-Δ<sup>9</sup>-tetrahydrocannabinol metabolites, and six amphetamine-type stimulants in human hair -
2020.07
| 공동저자
| ARTHRITIS & RHEUMATOLOGY, 제72권 7호, pp.1192-1202
Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis -
2020.06
| 공동저자
| PHARMACEUTICS, 제12권 6호
Effects of Decomplexation Rates on Ternary Gene Complex Transfection with alpha-Poly(L-Lysine) or epsilon-Poly(L-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell -
2020.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제21권 8호
Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis -
2020.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제21권 8호
Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome -
2020.04
| 교신저자
| JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Interactions between cyazofamid and human drug transporters -
2020.03
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1140권
Metabolite identification and profile of endosulfan sulfate in three human liver preparations using liquid chromatography-high resolution mass spectrometry -
2020.03
| 교신저자
| MOLECULES, 제25권 5호
Liquid chromatography-tandem mass spectrometry for the simultaneous determination of doxorubicin and its metabolites doxorubicinol, doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone in mouse plasma -
2020.03
| 교신저자
| PHARMACEUTICS, 제12권 3호
Mertansine inhibits mRNA expression and enzyme activities of cytochrome P450s and uridine 5′-diphospho-glucuronosyltransferases in human hepatocytes and liver microsomes -
2020.01
| 공동저자
| PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 제117권 1호, pp.584-594
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation -
2019.12
| 공동저자
| COLLOIDS AND SURFACES B-BIOINTERFACES, 제184권
Controlling complexation/decomplexation and sizes of polymer-based electrostatic pDNA polyplexes is one of the key factors in effective transfection -
2019.10
| 공동저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제519권 1호, pp.100-105
Clinical and biochemical relevance of monounsaturated fatty acid metabolism targeting strategy for cancer stem cell elimination in colon cancer -
2019.09
| 교신저자
| BIOMEDICAL CHROMATOGRAPHY, 제33권 9호
Simultaneous determination of 75 abuse drugs including amphetamines, benzodiazepines, cocaine, opioids, piperazines, zolpidem and metabolites in human hair samples using liquid chromatography–tandem mass spectrometry -
2019.08
| 공동저자
| SCIENTIFIC REPORTS, 제9권
Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells -
2019.08
| 교신저자
| MOLECULES, 제24권 16호
In vitro inhibitory effects of APINACA on human major cytochrome P450, UDP-glucuronosyltransferase enzymes, and drug transporters -
2019.07
| 교신저자
| PHARMACEUTICS, 제11권 7호
Identification of catalposide metabolites in human liver and intestinal preparations and characterization of the relevant sulfotransferase, UDP-glucuronosyltransferase, and carboxylesterase enzymes -
2019.07
| 공동저자
| MOLECULAR CARCINOGENESIS, 제58권 7호, pp.1221-1233
Epimagnolin targeting on an active pocket of mammalian target of rapamycin suppressed cell transformation and colony growth of lung cancer cells -
2019.06
| 공동저자
| MOLECULES, 제24권 11호
Epigallocatechin-3-gallate prevents acute gout by suppressing NLRP3 inflammasome activation and mitochondrial DNA synthesis -
2019.04
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제20권 8호
RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity -
2019.04
| 교신저자
| MOLECULES, 제24권 7호
A quantitative tandem mass spectrometry and scaled-down quechers approach for simultaneous analysis of pesticide multiresidues in human urine -
2019.02
| 교신저자
| MOLECULES, 제24권 4호
In Vitro Metabolism of 25B-NBF, 2-(4-Bromo-2, 5-Dimethoxyphenyl)-N-(2-Fluorobenzyl)ethanamine, in Human Hepatocytes Using Liquid Chromatography–Mass Spectrometry -
2019.01
| 교신저자
| MOLECULAR CARCINOGENESIS, 제58권 1호, pp.88-101
Magnolin targeting of ERK1/2 inhibits cell proliferation and colony growth by induction of cellular senescence in ovarian cancer cells -
2018.12
| 공동저자
| ANALYTICA CHIMICA ACTA, 제1037권, pp.281-292
Supported liquid extraction coupled to gas chromatography-selective mass spectrometric scan modes for serum steroid profiling -
2018.12
| 공동저자
| PHYTOTHERAPY RESEARCH, 제32권 12호, pp.2551-2559
Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome -
2018.10
| 공동저자
| ACTA PHARMACEUTICA SINICA B, 제8권 6호, pp.862-880
Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives -
2018.10
| 공동저자
| ADVANCED FUNCTIONAL MATERIALS, 제28권 40호, pp.201801918-201801918
Efficient Transdermal Delivery of DNA Nanostructures Alleviates Atopic Dermatitis Symptoms in NC/Nga Mice -
2018.09
| 교신저자
| PHARMACEUTICS, 제10권 3호
Simultaneous determination of chlorogenic acid isomers and metabolites in rat plasma using LC-MS/MS and its application to a pharmacokinetic study following oral administration of Stauntonia hexaphylla leaf extract (YRA-1909) to rats -
2018.09
| 교신저자
| MASS SPECTROMETRY LETTERS, 제9권 3호, pp.86-90
In vitro Metabolism of Methallylescaline in Human Hepatocytes Using Liquid Chromatography-High Resolution Mass Spectrometry -
2018.08
| 교신저자
| 약 학 회 지, 제62권 4호, pp.226-236
Effect of DA-9801 on the Expression of Drug-metabolizing Enzymes and Transporters in Human Hepatocytes -
2018.08
| 공동저자
| CLINICAL THERAPEUTICS, 제40권 8호, pp.1322-1337
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng -
2018.08
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제64권, pp.300-310
Dual-functionalized calcium nanocomplexes for transfection of cancerous and stem cells: Low molecular weight polycation-mediated colloidal stability and ATP-mediated endosomal release -
2018.08
| 공동저자
| FRONTIERS IN PHARMACOLOGY, 제9권
Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment -
2018.08
| 교신저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1092권, pp.114-121
Simultaneous quantification of 18 saturated and unsaturated fatty acids and 7 sterols as their tert-butyldimethylsilyl derivatives in human saliva using gas chromatography-tandem mass spectrometry -
2018.07
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제41권 7호, pp.691-710
Synthetic cannabinoids are substrates and inhibitors of multiple drug-metabolizing enzymes -
2018.07
| 공동저자
| BIOMACROMOLECULES, 제19권 7호, pp.2483-2495
Effects of the Physicochemical, Colloidal, and Biological Characteristics of Different Polymer Structures between α-Poly(l -lysine) and ϵ-Poly(l -lysine) on Polymeric Gene Delivery -
2018.06
| 교신저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 제81권 11호, pp.453-464
Absorption, metabolism, and excretion of [<sup>14</sup>C]evogliptin tartrate in male rats and dogs -
2018.04
| 공동저자
| RHEUMATOLOGY, 제57권 4호, pp.727-736
Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation -
2018.04
| 교신저자
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 제66권 13호, pp.3550-3560
Validation of a Multiresidue Analysis Method for 379 Pesticides in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry -
2018.04
| 교신저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1083권, pp.68-74
Metabolomics-assisted metabolite profiling of itraconazole in human liver preparations -
2018.04
| 교신저자
| MOLECULES, 제23권 4호
In vitro inhibitory effects of synthetic cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase enzyme activities in human liver microsomes -
2018.04
| 공동저자
| DRUG METABOLISM AND PHARMACOKINETICS, 제33권 2호, pp.111-117
Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes -
2018.03
| 공동저자
| CELL DEATH & DISEASE, 제9권 3호, pp.401-401
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis -
2018.02
| 교신저자
| 약 학 회 지, 제62권 1호, pp.1-6
Quantification of Ceftriaxone in Rat Plasma Using Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry -
2018.01
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1072권, pp.86-93
Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes -
2018.08
| 교신저자
| DRUG TESTING AND ANALYSIS, 제10권 8호, pp.1328-1335
Targeted and non-targeted metabolite identification of MAM-2201 in human, mouse, and rat hepatocytes -
2017.07
| 공동저자
| FITOTERAPIA, 제120권, pp.194-198
Investigation of pharmacokinetic parameters of bakuchicin isolated from Psoralea corylifolia in mice -
2017.07
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 7호
Mechanism investigation of rifampicin-induced liver injury using comparative toxicoproteomics in mice -
2017.06
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제40권 6호, pp.727-735
Inhibition of cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes -
2017.05
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 5호
Inhibitory effects of dimethyllirioresinol, epimagnolin a, eudesmin, fargesin, and magnolin on cytochrome P450 enzyme activities in human liver microsomes -
2017.04
| 교신저자
| MOLECULES, 제22권 4호
Multiple UDP-glucuronosyltransferase and sulfotransferase enzymes are responsible for the metabolism of verproside in human liver preparations -
2017.03
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 3호
Revisiting the metabolism and bioactivation of ketoconazole in human and mouse using liquid chromatography–mass spectrometry-based metabolomics -
2017.03
| 교신저자
| MOLECULES, 제22권 3호
AM-2201 inhibits multiple cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzyme activities in human liver microsomes -
2017.02
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제40권 2호, pp.180-196
Rapid analysis of drugs of abuse and their metabolites in human urine using dilute and shoot liquid chromatography–tandem mass spectrometry -
2017.02
| 교신저자
| ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 제409권 6호, pp.1667-1680
Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes -
2017.01
| 교신저자
| MOLECULES, 제32권 1호, pp.56-56
INHIBITORY EFFECTS OF ASCHANTIN ON CYTOCHROME P450 ENZYME ACTIVITIES IN HUMAN LIVER MICROSOMES -
2016.08
| 공동저자
| APPLIED BIOLOGICAL CHEMISTRY, 제59권 4호, pp.649-653
Biotransformation and molecular docking of cyazofamid by human liver microsomes and cDNA-expressed human recombinant P450s -
2016.07
| 공동저자
| SCIENTIFIC REPORTS, 제6권
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer -
2016.05
| 교신저자
| MOLECULES, 제21권 5호
Inhibitory effects of aschantin on cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzyme activities in human liver microsomes -
2016.04
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제39권 4호, pp.516-530
Comparative metabolism of honokiol in mouse, rat, dog, monkey, and human hepatocytes -
2016.03
| 교신저자
| ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 제408권 8호, pp.2069-2082
Lipidomic platform for structural identification of skin ceramides with alpha-hydroxyacyl chains -
2016.02
| 교신저자
| JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 제119권 0호, pp.50-58
In vitro metabolism of a novel synthetic cannabinoid, EAM-2201, in human liver microsomes and human recombinant cytochrome P450s -
2016.02
| 교신저자
| Journal of Pharmaceutical Investigation, 제46권 1호, pp.13-19
HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats -
2015.12
| 교신저자
| MOLECULES, 제20권 12호, pp.21802-21815
In vitro metabolic pathways of the new anti-diabetic drug evogliptin in human liver preparations -
2015.11
| 공동저자
| CARCINOGENESIS, 제36권 11호, pp.1372-1380
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17 -
2015.10
| 공동저자
| CARCINOGENESIS, 제36권 10호, pp.1223-1234
Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation -
2015.08
| 교신저자
| DRUG METABOLISM AND PHARMACOKINETICS, 제30권 4호, pp.305-313
Role of cytochrome P450 and UDP-glucuronosyltransferases in metabolic pathway of homoegonol in human liver microsomes -
2015.08
| 공동저자
| BMC CANCER, 제15권
Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway -
2015.04
| 공동저자
| DRUG METABOLISM AND PHARMACOKINETICS, 제30권 2호, pp.168-173
In vivo absorption and disposition of α-cedrene, a sesquiterpene constituent of cedarwood oil, in female and male rats -
2015.03
| 공동저자
| ELECTROPHORESIS, 제36권, pp.918-923
Differences in electrophoretic behavior between linear and branched PEG-conjugated proteins -
2015.02
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제38권, pp.171-177
"Metabolism-mediated drug interaction potential of HS-23, a new herbal drug for the treatment of sepsis in human hepatocytes and liver microsomes" -
2015.02
| 공동저자
| BIOLOGICAL & PHARMACEUTICAL BULLETIN, 제38권 2호, pp.208-217
Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats -
2015.01
| 교신저자
| DRUG DESIGN DEVELOPMENT AND THERAPY, 제9권 0호, pp.643-653
Organic anion transporter 3- and organic anion transporting polypeptides 1B1-and 1B3-mediated transport of catalposide -
2014.12
| 교신저자
| JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 제77권 0호, pp.1522-1532
Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes -
2014.12
| 교신저자
| JOURNAL OF PHARMACEUTICAL INVESTIGATION, 제44권 6호, pp.401-409
Evaluation of drug–drug interaction potential between DA-9801 and metformin -
2014.12
| 교신저자
| BIOMEDICAL CHROMATOGRAPHY, 제28권 12호, pp.1816-1821
Quantification of homoegonol in rat plasma using liquid chromatography-tandem mass spectrometry and its pharmacokinetics application -
2014.11
| 교신저자
| DRUG DESIGN DEVELOPMENT AND THERAPY, 제8권 0호, pp.2137-2145
Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes -
2014.07
| 교신저자
| BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 제14권 0호, pp.0-0
Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo -
2014.07
| 공동저자
| XENOBIOTICA, 제44권 7호, pp.635-643
Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats -
2014.03
| 교신저자
| ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 제406권 7호, pp.1917-1932
A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains -
2014.02
| 공동저자
| CARCINOGENESIS, 제35권 2호, pp.432-441
Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation -
2013.12
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제940권 0호, pp.94-103
Profiling analysis of biogenic amines and their acidic metabolites in mouse brain tissue using gas chromatography-tandem mass spectrometry -
2013.11
| 공동저자
| ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 제57권, pp.5448-5456
CYP2J2 and CYP2C19 Are the Major Enzymes Responsible for Metabolism of Albendazole and Fenbendazole in Human Liver Microsomes and Recombinant P450 Assay Systems -
2013.11
| 공동저자
| XENOBIOTICA, 제43권 11호, pp.985-992
Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats -
2013.11
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제36권, pp.3558-3562
GC-MS/MS method for the quantification of alpha-cedrene in rat plasma and its pharmacokinetic application -
2013.10
| 공동저자
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제440권 1호, pp.112-118
RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity -
2013.09
| 교신저자
| MOLECULES, 제18권 9호, pp.10681-10693
Effect of honokiol on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes -
2013.09
| 교신저자
| MASS SPECTROMETRY LETTERS, 제4권 3호, pp.55-58
Liquid chromatography-tandem mass spectrometry for quantification of dioscin in rat plasma -
2013.05
| 공동저자
| BIOPHARMACEUTICS & DRUG DISPOSITION, 제34권, pp.195-202
In vitro metabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes -
2013.02
| 공동저자
| PLOS ONE, 제8권 2호
Autophagy and Cellular Senescence Mediated by Sox2 Suppress Malignancy of Cancer Cells -
2013.01
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제36권, pp.1-5
Evaluation of DA-9801, a new herbal drug for diabetic neuropathy, on metabolism-mediated interaction -
2012.12
| 공동저자
| CARCINOGENESIS, 제33권 12호, pp.2529-2537
RSK2 as a key regulator in human skin cancer -
2012.12
| 공동저자
| JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제22권 12호, pp.1659-1664
Effect of TSHAC on Human Cytochrome P450 Activity, and Transport Mediated by P-Glycoprotein -
2012.10
| 교신저자
| MOLECULES, 제17권 10호, pp.11990-12002
In vitro and in vivo metabolism of verproside in rats -
2012.09
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제905권 0호, pp.113-117
Liquid chromatography-tandem mass spectrometry to determine the stability of collagen pentapeptide (KTTKS) in rat skin -
2012.06
| 공동저자
| CHROMATOGRAPHIA, 제75권 11-12호, pp.679-683
Application of sodium dodecyl sulfate-capillary gel electrophoresis to the characterization of ricin a-chain immunotoxins -
2012.05
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제35권 9호, pp.1102-1109
In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry -
2012.04
| 교신저자
| EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 제2012권 0호, pp.0-0
Effect of a new prokinetic agent DA-9701 formulated with corydalis tuber and pharbitidis semen on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes -
2012.02
| 교신저자
| BIOMEDICAL CHROMATOGRAPHY, 제26권 2호, pp.261-266
Hydrophilic interaction chromatography-electrospray ionization tandem mass spectrometric analysis of anastrozole in human plasma and its application to a pharmacokinetic study -
2012.01
| 교신저자
| MOLECULES, 제17권 1호, pp.851-860
Effect of efavirenz on UDP-glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 activities in human liver microsomes -
2011.12
| 공동저자
| BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 제32권 12호, pp.4253-4257
Characterization of two ricin isoforms by sodium dodecyl sulfate-capillary gel electrophoresis and capillary isoelectric focusing -
2011.11
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제34권, pp.1829-1842
Evaluation of Metabolism-Mediated Herb-Drug Interactions -
2011.12
| 공동저자
| AAPS PHARMSCITECH, 제12권 4호, pp.1220-1226
Reversible blocking of amino groups of octreotide for the inhibition of formation of acylated peptide impurities in poly(lactide-co-glycolide) delivery systems -
2011.08
| 교신저자
| JOURNAL OF SEPARATION SCIENCE, 제34권 15호, pp.1828-1833
Liquid chromatography-electrospray ionization tandem mass spectrometry for the quantification of styraxlignolide A in rat plasma -
2011.08
| 교신저자
| MOLECULES, 제16권 8호, pp.6591-6602
Corydaline inhibits multiple cytochrome P450 and UDP- glucuronosyltransferase enzyme activities in human liver microsomes -
2011.08
| 교신저자
| BIOMEDICAL CHROMATOGRAPHY, 제25권 8호, pp.879-889
Liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry for the simultaneous determination of dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, epimagnolin A, fargesin and magnolin in rat plasma -
2011.05
| 교신저자
| XENOBIOTICA, 제41권 5호, pp.358-371
In vitro metabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes -
2011.02
| 공동저자
| JOURNAL OF PHARMACEUTICAL SCIENCES, 제100권 2호, pp.482-491
Preparation and Characterization of Apo2L/TNF-Related Apoptosis-Inducing Ligand-Loaded Human Serum Albumin Nanoparticles with Improved Stability and Tumor Distribution -
2010.12
| 교신저자
| ARCHIVES OF PHARMACAL RESEARCH, 제33권 12호, pp.1985-1996
In Vitro Metabolism of Jaceosidin and Characterization of Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes
-
2021.09.02
| 공동발명자
| 가톨릭대학교 산학협력단
엔도솜 분해능 및 환원 분해성을 갖는 입실론-폴리(엘-라이신) 고분자 나노겔, 이의 제조방법 및 용도(ε-poly(L-lysine) polymer nanogel which has endosomolytic activity and reductive degradability, Its synthesis, and Use thereof) -
2013.08.08
| 공동발명자
| 원광대학교산학협력단
하고초 추출물을 포함하는 당뇨병성 죽상 경화증 치료 및 예방용 조성물(A composition for treating or preventing diabetic atherosclerosis comprising the extract of Prunella vulgaris) -
2012.07.19
| 공동발명자
| 원광대학교산학협력단
마치현 추출물을 유효성분으로 함유하는 당뇨병 및 당뇨 합병증 질환의 예방 또는 치료용 조성물(A composition comprising an extract of Portulaca oleracea for preventing or treating diabetes, diabetic complications)
-
2019.10.18
| 주발명자
| ㈜지투지바이오
“약물전달체의 약물동태 및 약동력학 바이오마커 분석기술’노하우 이전 -
2015.05.06
| 주발명자
| 영진약품공업㈜
"혈액 중 리마프로스트 검출을 위한 혈액샘플 전처리 과정" 노하우 이전