신계정 교수
Shin, Kye Jung
- 02-2164-4060
- kyejung@catholic.ac.kr
- 정진석추기경약학관 NP321
연구분야
신약 후보물질 개발 연구
연구키워드
면역 조절제
면역 항암제
교수소개
Rational design을 통한 신약 후보물질을 발굴하고 최적화하는 연구를 수행합니다. 발굴된 신약 후보물질은 국내 및 외국의 제약회사와의 공동연구나 licesing-out을 통하여 신약으로의 가능성을 검색하는 연구를 중점적으로 수행하고 있습니다. 현재 주 연구분야로 면역 관련 질환 치료제 개발를 진행하고 있습니다.
We perform the research to discover and optimize new drug candidates through rational design. We are focusing on research on finding out new drugs through joint research with domestic and foreign pharmaceutical companies. Currently, our main research area is developing new drugs for immune-related diseases.
최종학력
1996.02.29 | 서울대학교 | 약학과 | 박사
연구실적
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2023.12
| 공동저자
| Natural Product Sciences, 제29권 4호, pp.268-275
A New Bicyclic Megastigmane Derivative from By-product of Ginseng Berry Extract -
2022.08
| 공동저자
| MOLECULES, 제27권 16호
Non-Palladium-Catalyzed Approach to the Synthesis of (E)-3-(1,3-Diarylallylidene)Oxindoles -
2020.12
| 공동저자
| HETEROCYCLES, 제100권 12호, pp.2050-2060
Stereoselective Synthesis of (Z)-3-Arylidene-2-oxindoles via a Palladium-Catalyzed Tandem Reaction -
2020.11
| 공동저자
| JOURNAL OF SEPARATION SCIENCE, 제43권 21호, pp.4036-4046
Isolation of six anthraquinone diglucosides from cascara sagrada bark by high-performance countercurrent chromatography -
2020.11
| 공동저자
| MOLECULES, 제25권 21호
Total Synthesis of Cyclopiamide A Using Palladium-Catalyzed Domino Cyclization -
2020.02
| 공동저자
| EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 제188권
Thiazolidine-2,4-dione-based irreversible allosteric IKK-beta kinase inhibitors: Optimization into in vivo active anti-inflammatory agents -
2019.11
| 공동저자
| BIOORGANIC CHEMISTRY, 제92권
Optimization study towards more potent thiazolidine-2,4-dione IKK-beta modulator: Synthesis, biological evaluation and in silico docking simulation -
2018.12
| 공동저자
| HETEROCYCLES, 제96권 10호, pp.1795-1807
Palladium-Catalyzed One-Pot Approach to 3-(1,3-Diarylprop-2-ylidene)oxindoles -
2018.11
| 교신저자
| MOLECULES, 제23권 11호
Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy)phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells -
2018.09
| 공동저자
| EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 제157권, pp.691-704
Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-beta modulators -
2018.05
| 공동저자
| FORENSIC SCIENCE INTERNATIONAL, 제286권, pp.199-207
Isolation and structural characterization of a novel sibutramine analogue, chlorosipentramine, in a slimming dietary supplement, by using HPLC-PDA, LC-Q-TOF/MS, FT-IR, and NMR -
2018.01
| 공동저자
| JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 제1072권, pp.273-281
Identification and structural elucidation of a new sildenafil analogue, dithiopropylcarbodenafil, from a premixed powder intended as a dietary supplement -
2017.03
| 공동저자
| MOLECULES, 제22권 3호
Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles -
2017.02
| 공동저자
| JOURNAL OF ORGANIC CHEMISTRY, 제82권 3호, pp.1864-1871
Stereoselective Synthesis of 3-(1,3-Diarylallylidene)oxindoles via a Palladium-Catalyzed Tandem Reaction -
2016.09
| 공동저자
| MOLECULES, 제21권 9호
Aspirination of -Aminoalcohol (Sarpogrelate M1) -
2016.07
| 교신저자
| EUROPEAN JOURNAL OF PHARMACOLOGY, 제782권, pp.30-34
Protective effects of a dimeric derivative of ferulic acid in animal models of Alzheimer's disease -
2016.02
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제26권 4호, pp.1120-1123
Identification and characterization of potent, selective and metabolically stable IKK beta inhibitor -
2015.12
| 공동저자
| JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 제355권 3호, pp.362-369
Cinnamamides, Novel Liver X Receptor Antagonists that Inhibit Ligand-Induced Lipogenesis and Fatty Liver -
2015.10
| 공동저자
| SYNLETT, 제26권 16호, pp.2296-2300
Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)-oxindoles Using Microwave Irradiation -
2015.10
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제25권 20호, pp.4481-4486
Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent -
2015.08
| 공동저자
| HETEROCYCLES, 제91권 8호, pp.1660-1667
Synthesis of 2-(arylmethylene)-1,4-benzoxazin-3-one by one-pot sonogashira and 6-exo-dig cyclization -
2015.08
| 공동저자
| MOLECULES, 제20권 8호, pp.14022-14032
Palladium-catalyzed one-pot approach to 3-(Diarylmethylene)oxindoles from propiolamidoaryl triflate -
2015.02
| 교신저자
| JOURNAL OF MOLECULAR NEUROSCIENCE, 제56권, pp.263-272
Induction of NQO1 and Neuroprotection by a Novel Compound KMS04014 in Parkinson's Disease Models -
2014.12
| 공동저자
| DIGESTIVE DISEASES AND SCIENCES, 제59권 12호, pp.2975-2982
Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease -
2014.08
| 공동저자
| BIOCHEMICAL PHARMACOLOGY, 제90권 4호, pp.414-424
LXR-a antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver -
2014.02
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제24권 3호, pp.880-883
Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker -
2013.11
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제23권 21호, pp.5882-5886
2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of beta-amyloid aggregation -
2013.10
| 교신저자
| BRITISH JOURNAL OF ANAESTHESIA, 제111권, pp.667-672
Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice -
2013.09
| 공동저자
| SYNLETT, 제24권 15호, pp.1993-1997
Synthesis of 3-(Diarylmethylene)oxindoles via a Palladium-Catalyzed One-Pot Reaction: Sonogashira-Heck-Suzuki-Miyaura Combined Reaction -
2013.08
| 공동저자
| DRUG METABOLISM AND DISPOSITION, 제41권, pp.1529-1537
Glucuronidation of a Sarpogrelate Active Metabolite Is Mediated by UDP-Glucuronosyltransferases 1A4, 1A9, and 2B4 -
2012.12
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제22권 24호, pp.7555-7561
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease -
2012.09
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제22권 17호, pp.5668-5674
Discovery of potent and selective rhodanine type IKK beta inhibitors by hit-to-lead strategy -
2012.08
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY, 제20권 16호, pp.4921-4935
Small molecules that protect against beta-amyloid-induced cytotoxicity by inhibiting aggregation of beta-amyloid -
2011.10
| 교신저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제21권 19호, pp.5910-5915
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers -
2011.05
| 공동저자
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 제21권 10호, pp.3002-3006
Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors -
2011.02
| 공동저자
| JOURNAL OF MOLECULAR MODELING, 제17권 2호, pp.209-218
3D QSAR pharmacophore model based on diverse IKKβ inhibitors -
2011.01
| 공동저자
| BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 제32권 1호, pp.251-262
In silico Analysis on hERG Channel Blocking Effect of a Series of T-type Calcium Channel Blockers -
2006.12
| 공동저자
| HETEROCYCLES, 제70권, pp.143-143
An approach to cyclic alpha-amino acids by a novel hetero Diels-Alder/intramolecular hydantoin enolate alkylation strategy: An approach to halichlorine
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2013.02
| 공동
| 청문각
실험의약품합성학 -
2011.08
| 공동
| 신일북스
의약화학 -
2011.03
| 공동
| 동명사
의약품합성학
-
2020.04.22
| 공동발명자
| 가톨릭대학교 산학협력단
테트라하이드로파파베린 및 IL-6 억제제를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법(Composition for preventing or treating TNF-mediated diseases comprising tetrahydropapaverine and IL-6 inhibitor, and method for inhibiting TNF-activity with the same) -
2019.05.21
| 공동발명자
| 가톨릭대학교 산학협력단
신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법(Composition for Preventing or Treating TNF-mediated Disease Comprising Novel Derivatives and Method for Inhibiting TNF-activity with the Same) -
2018.12.26
| 주발명자
| 가톨릭대학교 산학협력단
신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법
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2022.08.01
| 공동발명자
| ㈜아이랩
“IL-6 생리활성을 억제하는 저분자화합물 발굴을 위한 탐색적 연구” 의 기술·노하우 이전 -
2019.08.19
| 공동발명자
| ㈜아이랩
‘신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제방법’의 특허양도(매매) 건 -
2017.11.22
| 공동발명자
| (주)아이랩
‘신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제방법’의 기술이전 건