성심산학협력단

 

연구정보

연구자현황

정정민(Chung Jeongmin) 프로필 이미지 학과장

정정민 조교수

Chung Jeongmin

연구분야

생명공학, 구조생물학

연구키워드

구조생화학 (CryoEM) 병원체 바이오의약품 바이오이미징

교수소개


						
정정민 교수는 University of Auckland (New Zealand)와 강원대학교에서 학사, 석/박사 학위를 받았으며, University of Michigan (USA)에서  박사후연구원으로 재직 후,  2021년 3월부터 가톨릭대학교 생명공학과에서 조교수로 재직 중에 있다. Cryo-electron microscopy (Cryo-EM) 및 Cryo-electron tomography (Cryo-ET)를 비롯한 첨단 바이오이미징 기술을 활용하여 생명체 내 주요 고분자의 구조와 기능에 대한 연구를 수행 중이다. 특히 다제내성 감염성 질환에 대한 새로운 치료제 및 백신 개발에 필요한 기초 연구를 진행 중이며, 바이오이미징 전산처리에 접목 가능한 딥러닝 알고리즘 플랫폼 개발 또한 추진 중에 있다. Biophysical Society (USA), Microscopy Society of America (USA), 한국구조생물학회(KSSB), 한국현미경학회(KSM), 한국생명공학회(KSBB), 한국생화학분자생물학회(KSBMB), 한국분자세포생물학회(KSMCB)의 정회원이며, 한국 Cryo-EM 사용자 협회(KOCUA)의 운영위원, 한국단백질과학회(KSPS)의 집행위원, 그리고 한국미생물생명공학회(KMB)의 이사회 위원으로 활동하며 한국 및 글로벌 생명공학 발전에 중요한 역할을 하고 있다.
Professor Jeong Min Chung received his bachelor's and master's/Ph.D. degrees from the University of Auckland (New Zealand) and Kangwon National University. After serving as a postdoctoral researcher at the University of Michigan (USA), he has been an assistant professor in the Department of Biotechnology at the Catholic University of Korea since March 2021. He is conducting research on the structure and function of major macromolecules within living organisms using advanced bioimaging technologies, including Cryo-electron microscopy (Cryo-EM) and Cryo-electron tomography (Cryo-ET). In particular, he is working on foundational research necessary for the development of new therapeutics and vaccines for multi-drug resistant infectious diseases and is also developing a deep learning algorithm platform that can be integrated with bioimaging computational processing. 

최종학력

2018.02.22 | 강원대학교 | 생화학과 | 이학박사

연구실적

  • 2024.06 | 교신저자 | JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 제15권 1호
    Assessing the interplay of contrast, defocus, and resolution in cryo-EM: a benchmark experiment for limited dataset screening
  • 2024.04 | 교신저자 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제702권
    Optimizing protein crosslinking control: Synergistic quenching effects of glycine, histidine, and lysine on glutaraldehyde reactions
  • 2023.12 | 교신저자 | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 제33권 12호, pp.1543-1551
    Comparative Analysis of T4SS Molecular Architectures
  • 2022.11 | 교신저자 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 제10권
    Studies of functional properties of espin 1: Its interaction to actin filaments
  • 2022.08 | 제1저자 | LIFE, 제12권 8호
    Artificial Intelligence in Cryo-Electron Microscopy
  • 2022.07 | 공동저자 | MICROSCOPY AND MICROANALYSIS, 제28권, pp.1134-1135
    Cryo-EM Reveals New Species-specific Proteins and Symmetry Elements in the Legionella pneumophila Dot/Icm T4SS
  • 2022.07 | 공동저자 | JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 제13권 1호
    Comparative analysis of human and bovine thyroglobulin structures
  • 2022.06 | 제1저자 | LIFE, 제12권 6호
    Structural Analysis of Human Fascin-1: Essential Protein for Actin Filaments Bundling
  • 2022.05 | 공동저자 | SCIENCE ADVANCES, 제8권 19호
    Molecular architecture of the human caveolin-1 complex
  • 2022.02 | 공동저자 | BIOPHYSICAL JOURNAL, 제121권 3호, pp.2-2
    The building blocks of caveolae, revealed
  • 2021.10 | 교신저자 | JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 제12권 1호
    Microscopic studies on severing properties of actin-binding protein: its potential use in therapeutic treatment of actin-rich inclusions
  • 2021.09 | 공동저자 | ELIFE, 제10권
    Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS
  • 2020.09 | 공동저자 | ELIFE, 제9권
    Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex
  • 2020.09 | 제1저자 | ELIFE, 제9권
    Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex
  • 2020.03 | 제1저자 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 제63권 6호, pp.2930-2940
    Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug
  • 2019.06 | 제1저자 | ELIFE, 제8권
    Structure of the Helicobacter pylori Cag type IV secretion system
  • 2018.11 | 공동저자 | ULTRAMICROSCOPY, 제194권, pp.35-39
    Analysis of nano-crystals: Evaluation of heavy metal-embedded biological specimen by high voltage electron microscopy
  • 2018.09 | 제1저자 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제503권 3호, pp.1836-1840
    The actin bundling activity of actin bundling protein 34 is inhibited by calcium binding to the EF2
  • 2018.01 | 제1저자 | APPLIED SPECTROSCOPY REVIEWS, 제53권 2-4호, pp.195-202
    Cryo-electron tomography: A tool for in situ structural analysis of macromolecular complexes
  • 2017.12 | 제1저자 | 한국현미경학회지, 제47권 4호, pp.223-225
    Toward High-Resolution Cryo-Electron Microscopy: Technical Review on Microcrystal-Electron Diffraction
  • 2017.09 | 제1저자 | 한국현미경학회지, 제47권 3호, pp.160-164
    Recent Advances in Electron Crystallography
  • 2017.07 | 공동저자 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제489권 2호, pp.217-222
    Characterisation of conformational and functional features of alkyl hydroperoxide reductase E-like protein
  • 2017.05 | 제1저자 | PROTEIN EXPRESSION AND PURIFICATION, 제133권, pp.193-198
    Effective non-denaturing purification method for improving the solubility of recombinant actin-binding proteins produced by bacterial expression
  • 2017.01 | 공동저자 | PROTOPLASMA, 제254권 1호, pp.327-334
    Site-specific mutagenesis of yeast 2-Cys peroxiredoxin improves heat or oxidative stress tolerance by enhancing its chaperone or peroxidase function
  • 2016.05 | 공동저자 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 제16권 5호, pp.4593-4597
    Technical Advances in Intracellular Detection Using Immuno-Gold Particles: Simple Cryofixation with Metal Contact Quick Freezing
  • 2016.04 | 공동저자 | JOURNAL OF BIOLOGICAL CHEMISTRY, 제291권 16호, pp.8575-8590
    Molecular Insights into Toluene Sensing in the TodS/TodT Signal Transduction System
  • 2016.03 | 제1저자 | 한국현미경학회지, 제46권 1호, pp.1-5
    Advanced Cryo-Electron Microscopy Technology: High Resolution Structure of Macromolecules
  • 2016.01 | 제1저자 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 제469권 4호, pp.1028-1033
    New insight into multifunctional role of peroxiredoxin family protein: Determination of DNA protection properties of bacterioferritin comigratory protein under hyperthermal and oxidative stresses
  • 2015.12 | 공동저자 | JOURNAL OF BIOLOGICAL CHEMISTRY, 제290권 49호, pp.29313-29328
    Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains
  • 2015.09 | 제1저자 | 한국현미경학회지, 제45권 3호, pp.150-154
    The Effects of Electron Beam Exposure Time on Transmission Electron Microscopy Imaging of Negatively Stained Biological Samples
  • 2016.12.22 | 공동발명자 | 강원대학교산학협력단
    미스트 분사 및 급냉식 원자간력 현미경용 시편 처리장치(Apparatus for preparing biological specimens of atomic force microscopy using mist-spray and quick freezing)